2-Chloro-5-fluoro-3,4-pyridinediamine

Product Name: 2-Chloro-5-fluoro-3,4-pyridinediamine
CAS No.: 405230-93-5
Chemical Name: 2-Chloro-5-fluoro-3,4-pyridinediamine
Synonyms: 2-Chloro-5-fluoropyridine-3,4-diaMine;2-Chloro-5-fluoro-3,4-pyridinediamine;2-CHLORO-3,4-DIAMINO-5-FLUOROPYRIDINE;3,4-PyridinediaMine, 2-chloro-5-fluoro-
CBNumber: CB52500646
Molecular Formula: C5H5ClFN3
Formula Weight: 161.56
MOL File: 405230-93-5.mol

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2-Chloro-5-fluoro-3,4-pyridinediamine Property

Density: 1.562
storage temp.: Keep in dark place,Inert atmosphere,Room temperature

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C374028
Product name: 2-chloro-5-fluoropyridine-3,4-diamine
Packaging: 5mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: W6104
Product name: 2-Chloro-5-fluoropyridine-3,4-diamine
Packaging: 100mg
Price: $169
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: G14270
Product name: 2-Chloro-5-fluoro-3,4-pyridinediamine
Packaging: 250mg
Price: $180
Updated: 2021/12/16

AK Scientific

Product number: W6104
Product name: 2-Chloro-5-fluoropyridine-3,4-diamine
Packaging: 250mg
Price: $239
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: G14270
Product name: 2-Chloro-5-fluoro-3,4-pyridinediamine
Packaging: 500mg
Price: $270
Updated: 2021/12/16

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2-Chloro-5-fluoro-3,4-pyridinediamine Chemical Properties,Usage,Production

Synthesis

405230-90-2

405230-93-5

General procedure for the synthesis of 2-chloro-3,4-diamino-5-fluoropyridine from 2-chloro-5-fluoro-3-nitropyridin-4-amine: a mixture of 4-amino-2-chloro-5-fluoro-3-nitropyridine (0.45 g, 2.3 mmol) and nickel ruanide (0.6 g) in anhydrous ethanol (10 mL) was placed in the Parr hydrogenation apparatus at 36 rpm The hydrogenation reaction was carried out. The progress of the reaction was monitored by thin layer chromatography (TLC) until the starting material completely disappeared. Upon completion of the reaction, the catalyst was removed by filtration and carefully washed with ethanol (2 x 10 mL). The filtrates were combined and the solvent was removed by vacuum evaporation to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: dichloromethane/ethanol, 20:1, v/v) to afford the target compound 2-chloro-3,4-diamino-5-fluoropyridine (0.26 g, yield: 68%). The structure of the product was confirmed by 1H NMR (DMSO-d6, 400 MHz), δ 7.45 (d, J = 2.0 Hz, 1H), 5.80 (br s, 2H), 4.98 (br s, 2H).

References

[1] Nucleosides, Nucleotides and Nucleic Acids, 2001, vol. 20, # 12, p. 1975 - 2000
[2] Patent: WO2011/113802, 2011, A2. Location in patent: Page/Page column 108

2-Chloro-5-fluoro-3,4-pyridinediamine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-5-fluoro-3,4-pyridinediamine Suppliers

China 36 India 1 United States 8 Global 45

J & K SCIENTIFIC LTD.

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View Lastest Price from 2-Chloro-5-fluoro-3,4-pyridinediamine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Chloro-5-fluoro-3,4-pyridinediamine 405230-93-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-18

Career Henan Chemical Co

Product: 2-Chloro-5-fluoro-3,4-pyridinediamine 405230-93-5
Price: US $1.00-2.00/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2019-08-28

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2-CHLORO-3,4-DIAMINO-5-FLUOROPYRIDINE

405230-93-5