(2-Chloropyridin-3-yl)acetonitrile
- Product Name
- (2-Chloropyridin-3-yl)acetonitrile
- CAS No.
- 101012-32-2
- Chemical Name
- (2-Chloropyridin-3-yl)acetonitrile
- Synonyms
- 2-Chloro-3-pyridineaceton...;2-Chloropyridine-3-acetonitrile;2-Chloro-3-pyridineacetonitrile;2-Chloro-3-(cyanomethyl)pyridine;3-Pyridineacetonitrile, 2-chloro-;(2-Chloropyridin-3-yl)acetonitrile;2-(2-Chloro-3-pyridyl)acetonitrile;(2-Chloro-3-pyridinyl)acetonitrile;2-(2-Chloropyridin-3-yl)acetonitrile;(2-Chloropyridin-3-yl)acetonitrile 97%
- CBNumber
- CB52500691
- Molecular Formula
- C7H5ClN2
- Formula Weight
- 152.58
- MOL File
- 101012-32-2.mol
(2-Chloropyridin-3-yl)acetonitrile Property
- Melting point:
- 85-86 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4))
- Boiling point:
- 294.1±25.0 °C(Predicted)
- Density
- 1.262±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.43±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C7H5ClN2/c8-7-6(3-4-9)2-1-5-10-7/h1-2,5H,3H2
- InChIKey
- DMWOJKQPJYWCCB-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC=C1CC#N
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B405188
- Product name
- 2-(2-Chloropyridin-3-yl)acetonitrile
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FC144047
- Product name
- 2-(2-Chloropyridin-3-yl)acetonitrile
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FC144047
- Product name
- 2-(2-Chloropyridin-3-yl)acetonitrile
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FC144047
- Product name
- 2-(2-Chloropyridin-3-yl)acetonitrile
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 3H37-5-X8
- Product name
- (2-Chloropyridin-3-yl)acetonitrile
- Purity
- 95%
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
(2-Chloropyridin-3-yl)acetonitrile Chemical Properties,Usage,Production
Uses
2-(2-Chloropyridin-3-yl)acetonitrile is a useful reagent in the preparation of spirocyclic oxindole analog(spiro[piperidine-4,3''-pyrrolo[2,3-b]pyridin]-2''(1''H)-one) with anti-tumor properties.
Synthesis
6635-88-7
101012-32-2
The general procedure for the synthesis of (2-chloropyridin-3-yl)acetonitrile from (1-yloxy-pyridin-3-yl)-acetonitrile is as follows: 1. under vigorous stirring, (1 -oxy-pyridin-3-yl)acetonitrile (7.5 g, 35.9 mmol) was slowly added to phosphoryl chloride (100 mL). 2. The reaction mixture was slowly heated to 80°C in 5°C increments over 1.5 hours. (Note: too rapid a heating rate may result in violent decomposition at about 70°C.) 3. Allow all solids to dissolve and continue heating to reflux for 3 hours. 4. When the reaction is complete, carefully remove the excess phosphorus trichloride and dispose of the residue in cold water. 5. The mixture was adjusted to alkaline by adding saturated sodium bicarbonate solution and subsequently extracted with ethyl acetate (3 x). 6. The organic extracts were combined, washed with brine, dried, filtered and concentrated. 7. Purify the residue by column chromatography with an elution gradient of pentane to 100% ether. 8. The second eluted compound from the column chromatography, the target product (2-chloropyridin-3-yl)acetonitrile (2.35 g, 42.9% yield), was collected as a light brown solid.
References
[1] Patent: US2005/54631, 2005, A1. Location in patent: Page/Page column 23-24
[2] Patent: WO2014/27199, 2014, A1. Location in patent: Page/Page column 141
[3] Journal of the American Chemical Society, 1959, vol. 81, p. 740,742
[4] Patent: WO2012/110773, 2012, A1. Location in patent: Page/Page column 138; 139
(2-Chloropyridin-3-yl)acetonitrile Preparation Products And Raw materials
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View Lastest Price from (2-Chloropyridin-3-yl)acetonitrile manufacturers
- Product
- (2-Chloropyridin-3-yl)acetonitrile 101012-32-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-03
- Product
- (2-Chloropyridin-3-yl)acetonitrile 101012-32-2
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 98%min
- Supply Ability
- G/KG/T
- Release date
- 2019-12-23