4-Fluoro-2-iodophenol
- Product Name
- 4-Fluoro-2-iodophenol
- CAS No.
- 2713-29-3
- Chemical Name
- 4-Fluoro-2-iodophenol
- Synonyms
- 2-Iodo-4-fluorophenol;4-Fluoro-2-iodophenol;Phenol, 4-fluoro-2-iodo-;4-Fluoro-2-iodophenol95%;4-Fluoro-2-iodophenol 95%;5-Fluoro-2-hydroxyiodobenzene;4-Fluoro-1-hydroxy-2-iodobenzene
- CBNumber
- CB52501719
- Molecular Formula
- C6H4FIO
- Formula Weight
- 238
- MOL File
- 2713-29-3.mol
4-Fluoro-2-iodophenol Property
- Melting point:
- 120-123℃
- Boiling point:
- 196℃
- Density
- 2.085
- Flash point:
- 73℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- crystalline solid
- pka
- 8.53±0.18(Predicted)
- color
- Orange to brown
Safety
- HS Code
- 2907290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- F401590
- Product name
- 4-Fluoro-2-iodophenol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 2601-K-01
- Product name
- 4-Fluoro-2-iodophenol
- Packaging
- 25g
- Price
- $328
- Updated
- 2021/12/16
- Product number
- 089915
- Product name
- 4-Fluoro-2-iodophenol
- Purity
- 95+%
- Packaging
- 10g
- Price
- $133
- Updated
- 2021/12/16
- Product number
- Z4529
- Product name
- 4-Fluoro-2-iodophenol
- Packaging
- 10g
- Price
- $229
- Updated
- 2021/12/16
- Product number
- 089915
- Product name
- 4-Fluoro-2-iodophenol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
4-Fluoro-2-iodophenol Chemical Properties,Usage,Production
Synthesis
371-41-5
2713-29-3
General procedure for the synthesis of 4-fluoro-2-iodophenol from 4-fluorophenol: Methanol (200 mL), 4-fluorophenol (8.00 g, 71.37 mmol), sodium iodide (12.84 g, 85.64 mmol), and sodium hydroxide (3.43 g, 85.64 mmol) were added to a round-bottomed flask fitted with a dosing funnel under nitrogen protection, maintaining the reaction temperature at 0-10°C. After stirring for 15 min, sodium hypochlorite solution (133 mL, 5% v/v, commercially available bleach, 92.77 mmol) was slowly added dropwise. After the dropwise addition was completed, stirring was continued at 0-10 °C for 1 hour. Subsequently, 100 mL of 10 wt% aqueous sodium thiosulfate was added to the reaction mixture. After acidifying the reaction mixture with 5% hydrochloric acid, it was extracted with dichloromethane (500 mL). The organic phase was washed sequentially with 500 mL of 10 wt% aqueous sodium thiosulfate solution, water and saturated saline, and then dried with anhydrous magnesium sulfate. The dried organic phase was filtered through a silica gel pad and concentrated to give an oily crude product. The crude product was purified by recrystallization from hexane to give 11.52 g of pure product in white crystal form in 67.8% yield. The structure of the product was confirmed by 1H NMR, 13C NMR and mass spectrometry: 1H NMR (500 MHz, chloroform-d) δ 7.36 (dd, J = 7.6, 2.9 Hz, 1H), 6.97 (ddd, J = 8.9, 7.7, 2.9 Hz, 2H), 6.92 (dd, J = 9.0, 4.9 Hz, 1H), 5.10 (s, 1H) ; 13C NMR (101 MHz, chloroform-d) δ 156.42 (d, J = 243.0 Hz), 151.45 (d, J = 2.6 Hz), 124.34 (d, J = 25.3 Hz), 116.83 (d, J = 23.1 Hz), 115.08 (d, J = 7.8 Hz), 84.23 (d, J = 9.0 Hz ); MS m/e 238.
References
[1] Journal of the Brazilian Chemical Society, 2010, vol. 21, # 1, p. 3 - 6
[2] Chemical Communications, 2016, vol. 52, # 29, p. 5152 - 5155
[3] Organic and Biomolecular Chemistry, 2017, vol. 15, # 9, p. 1956 - 1960
[4] Patent: WO2016/89935, 2016, A1. Location in patent: Page/Page column 27; 28
[5] Tetrahedron Letters, 2010, vol. 51, # 16, p. 2170 - 2173
4-Fluoro-2-iodophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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