1-Boc-4-(3-Iodo-1H-indazol-4-yl)piperazine

Product Name: 1-Boc-4-(3-Iodo-1H-indazol-4-yl)piperazine
CAS No.: 744219-32-7
Chemical Name: 1-Boc-4-(3-Iodo-1H-indazol-4-yl)piperazine
Synonyms: 1-Boc-4-(3-Iodo-1H-indazol-4-yl);1-Boc-4-(3-Iodo-1H-indazol-4-yl)piperazine;tert-butyl 4-(3-iodo-1H-indazol-4-yl)piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-(3-iodo-1H-indazol-4-yl)-, 1,1-dimethylethyl ester
CBNumber: CB52502675
Molecular Formula: C16H21IN4O2
Formula Weight: 428.27
MOL File: 744219-32-7.mol

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1-Boc-4-(3-Iodo-1H-indazol-4-yl)piperazine Property

Boiling point:: 541.7±50.0 °C(Predicted)
Density: 1.599±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 14.37±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB144031
Product name: tert-Butyl 4-(3-iodo-1H-indazol-4-yl)piperazine-1-carboxylate
Packaging: 5mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144031
Product name: tert-Butyl 4-(3-iodo-1H-indazol-4-yl)piperazine-1-carboxylate
Packaging: 10mg
Price: $120
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144031
Product name: tert-Butyl 4-(3-iodo-1H-indazol-4-yl)piperazine-1-carboxylate
Packaging: 25mg
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144031
Product name: tert-Butyl 4-(3-iodo-1H-indazol-4-yl)piperazine-1-carboxylate
Packaging: 50mg
Price: $350
Updated: 2021/12/16

AK Scientific

Product number: W8213
Product name: 1-Boc-4-(3-iodo-1H-indazol-4-yl)piperazine
Packaging: 250mg
Price: $374
Updated: 2021/12/16

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1-Boc-4-(3-Iodo-1H-indazol-4-yl)piperazine Chemical Properties,Usage,Production

Synthesis

744219-31-6

744219-32-7

Example 104 Preparation of 4-[4-(tert-butoxycarbonyl)piperazin-1-yl]-3-iodo-1H-indazole: tert-butyl 4-(1H-indazol-4-yl)piperazine-1-carboxylate (5.00 g, 16.5 mmol) was dissolved in N,N-dimethylformamide and powdered potassium hydroxide (1.85 g, 33.07 mmol) and iodine (4.61 g (18.2 mmol). The reaction mixture was stirred at room temperature for 16 h and then diluted with ethyl acetate. The reaction was quenched with 15% aqueous sodium metabisulfite. The organic and aqueous phases were separated and the aqueous phase was extracted with ethyl acetate. The organic phase and extract were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated in vacuum to give the crude product. The crude product was purified by column chromatography (silica gel, eluent ratio 10:90 to 15:85 to 20:80 ethyl acetate/hexane) to give the title compound as a yellow solid (2.40 g, 35% yield). The structure of the product was confirmed by 1H NMR and mass spectrometry.

References

[1] Patent: US2004/167122, 2004, A1. Location in patent: Page/Page column 20
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 21, p. 7639 - 7646

1-Boc-4-(3-Iodo-1H-indazol-4-yl)piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-4-(3-Iodo-1H-indazol-4-yl)piperazine Suppliers

China 23 Germany 1 India 1 United Kingdom 1 United States 4 Global 30

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744219-32-7, 1-Boc-4-(3-Iodo-1H-indazol-4-yl)piperazineRelated Search:

1-Boc-4-(3-Iodo-1H-indazol-4-yl)piperazine

1-Boc-4-(3-Iodo-1H-indazol-4-yl)

tert-butyl 4-(3-iodo-1H-indazol-4-yl)piperazine-1-carboxylate

1-Piperazinecarboxylic acid, 4-(3-iodo-1H-indazol-4-yl)-, 1,1-dimethylethyl ester

744219-32-7

C16H21IN4O2