ChemicalBook > CAS DataBase List > Akt Inhibitor X

Akt Inhibitor X

Product Name
Akt Inhibitor X
CAS No.
925681-41-0
Chemical Name
Akt Inhibitor X
Synonyms
10-NCP;10-DEBC HCl;Akt Inhibitor X;10-NCP (10-DEBC;SVKSJUIYYCQZEC-UHFFFAOYSA-N;N-diethyl-10H-phenoxazine-10-butanamine;2-Chloro-N,N-diethyl-10H-phenoxazine-10-butanamine hydrochloride (1:1)
CBNumber
CB52503238
Molecular Formula
C20H26Cl2N2O
Formula Weight
381.34
MOL File
925681-41-0.mol
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Akt Inhibitor X Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
color 
White to off-white
Water Solubility 
Soluble to 100mM in water or DMSO
Sensitive 
Light Sensitive & Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
124039
Product name
InSolution Akt Inhibitor X - CAS 925681-41-0 - Calbiochem
Packaging
2mg
Price
$201
Updated
2024/03/01
Sigma-Aldrich
Product number
124020
Product name
Akt Inhibitor X - CAS 925681-41-0 - Calbiochem
Packaging
5mg
Price
$241.8
Updated
2024/03/01
Alfa Aesar
Product number
J65119
Product name
Akt Inhibitor X
Packaging
5mg
Price
$190.05
Updated
2023/01/06
Cayman Chemical
Product number
14863
Product name
Akt Inhibitor X
Purity
≥95%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
14863
Product name
Akt Inhibitor X
Purity
≥95%
Packaging
5mg
Price
$135
Updated
2024/03/01
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Akt Inhibitor X Chemical Properties,Usage,Production

Description

Akt functions as a key component in multiple signaling pathways to promote cell survival by mediating resistance to apoptosis. Akt inhibitor X is a cell permeable phenoxazine derivative that suppresses insulin-like growth factor 1 (IGF-1)-stimulated phosphorylation of Akt with an IC50 value of 1-2 μM. This compound has been shown to block IGF-1-stimulated nuclear translocation of Akt in Rh1 cells and to inhibit the growth of Rh1, Rh18, and Rh30 cells with IC50 values of 2-5 μM. Inhibition of Akt phosphorylation by 5 μM of this compound strongly correlates to the inhibition of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein and to an increase in apoptosis.

Uses

Akt Inhibitor X is used as a cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity.

storage

Desiccate at +4°C

References

[1]. janjetovic k, vucicevic l, misirkic m, et al. metformin reduces cisplatin-mediated apoptotic death of cancer cells through ampk-independent activation of akt. european journal of pharmacology, 2011, 651(1): 41-50.
[2]. de abreu la, calixto c, waltero cf, et al. the conserved role of the akt/gsk3 axis in cell survival and glycogen metabolism in rhipicephalus (boophilus) microplus embryo tick cell line bme26. biochimica et biophysica acta (bba)-general subjects, 2013, 1830(3): 2574-2582.
[3]. brunet a, bonni a, zigmond mj, et al. akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. cell, 1999, 96(6): 857-868.
[4]. pulinilkunnil t, he h, kong d, et al. adrenergic regulation of amp-activated protein kinase in brown adipose tissue in vivo. journal of biological chemistry, 2011, 286(11): 8798-8809.

Akt Inhibitor X Preparation Products And Raw materials

Raw materials

Preparation Products

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Akt Inhibitor X Suppliers

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925681-41-0, Akt Inhibitor XRelated Search:

Loratadine

  • Akt Inhibitor X
  • 10-DEBC HCl
  • 2-Chloro-N,N-diethyl-10H-phenoxazine-10-butanamine hydrochloride (1:1)
  • SVKSJUIYYCQZEC-UHFFFAOYSA-N
  • 10-NCP (10-DEBC
  • 10-NCP
  • N-diethyl-10H-phenoxazine-10-butanamine
  • 925681-41-0
  • C20H25ClN2OHCl