ChemicalBook > CAS DataBase List > 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester

3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester

Product Name
3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
CAS No.
858643-92-2
Chemical Name
3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
Synonyms
tert-butyl 3-acetylpiperidine-1-carboxylate;1-Boc-3-acetylpiperidine;1-Boc-3-acetylpiperidine - [A13489];1,1-Dimethylethyl 3-acetyl-1-piperidinecarboxylate;3-Acetyl-1-piperidinecarboxylic acid tert-butyl ester;3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 3-acetyl-, 1,1-dimethylethyl es...;1-Piperidinecarboxylic acid, 3-acetyl-, 1,1-diMethylethyl ester
CBNumber
CB52506466
Molecular Formula
C12H21NO3
Formula Weight
227.3
MOL File
858643-92-2.mol
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3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Property

Boiling point:
312.4±35.0 °C(Predicted)
Density 
1.052
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-2.40±0.40(Predicted)
Appearance
Colorless to off-white Solid
InChI
InChI=1S/C12H21NO3/c1-9(14)10-6-5-7-13(8-10)11(15)16-12(2,3)4/h10H,5-8H2,1-4H3
InChIKey
IIDISJMZFQAYKG-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCCC(C(C)=O)C1
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
B750938
Product name
tert-Butyl3-Acetylpiperidine-1-carboxylate
Packaging
500mg
Price
$220
Updated
2021/12/16
Apolloscientific
Product number
OR909709
Product name
1-Boc-3-acetyl-piperidine
Purity
97%
Packaging
1g
Price
$54
Updated
2021/12/16
Synthonix
Product number
A13489
Product name
1-Boc-3-acetylpiperidine
Purity
95+%
Packaging
250mg
Price
$95
Updated
2021/12/16
Matrix Scientific
Product number
123520
Product name
1-Boc-3-acetylpiperidine
Purity
95+%
Packaging
1g
Price
$594
Updated
2021/12/16
Apolloscientific
Product number
OR909709
Product name
1-Boc-3-acetyl-piperidine
Purity
97%
Packaging
5g
Price
$166
Updated
2021/12/16
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3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

75-16-1

189442-78-2

858643-92-2

Methylmagnesium bromide (1.4 M toluene/THF 75/25, 268 mL) was slowly added dropwise to a solution of 1-Boc-N-methoxy-N-methylpiperidine-3-carboxamide (59 g, 0.22 mol) in tetrahydrofuran (THF, 250 mL) at 0 °C and protected by nitrogen, and the temperature of the reaction was controlled not to exceed 15 °C. After dropwise addition, the reaction mixture was stirred at room temperature for 1 hour. Subsequently, the reaction mixture was slowly poured into an ice-water mixture containing 100 mL of ice-acetic acid. The product was extracted with ether (Et2O) and the organic layer was washed with 5% sodium bicarbonate (NaHCO3) solution. The organic layer was dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give tert-butyl 3-acetylpiperidine-1-carboxylate (50 g, quantitative yield).

References

[1] Patent: WO2018/154133, 2018, A1. Location in patent: Page/Page column 48
[2] Patent: US2006/183761, 2006, A1. Location in patent: Page/Page column 27
[3] Journal of Organic Chemistry, 2009, vol. 74, # 5, p. 1932 - 1938
[4] Patent: WO2010/36589, 2010, A1. Location in patent: Page/Page column 62
[5] Patent: WO2012/58127, 2012, A2. Location in patent: Page/Page column 80

3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Suppliers

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View Lastest Price from 3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester manufacturers

Career Henan Chemical Co
Product
3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester 858643-92-2
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-08
Career Henan Chemical Co
Product
3-Acetyl-piperidine-1-carboxylic acid tert-butyl ester 858643-92-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2020-01-08

858643-92-2, 3-Acetyl-piperidine-1-carboxylic acid tert-butyl esterRelated Search:

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