ChemicalBook > CAS DataBase List > tert-Butyl (4-chloro-3-formylpyridin-2-yl)carbamate
tert-Butyl (4-chloro-3-formylpyridin-2-yl)carbamate
- Product Name
- tert-Butyl (4-chloro-3-formylpyridin-2-yl)carbamate
- CAS No.
- 868736-42-9
- Chemical Name
- tert-Butyl (4-chloro-3-formylpyridin-2-yl)carbamate
- Synonyms
- KML-82;KML-114;CAS:868736-42-9;2-(Boc-aMino)-4-chloronicotinaldehyde;2-(BOC-AMINO)-4-CHLORO-3-FORMYLPYRIDINE;tert-butyl N-(4-chloro-3-formyl-2-pyridyl)carbamate;tert-Butyl (4-chloro-3-formylpyridin-2-yl)carbamate;tert-butyl N-(4-chloro-3-forMylpyridin-2- yl)carbaMate;Carbamic acid, N-(4-chloro-3-formyl-2-pyridinyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB52507034
- Molecular Formula
- C11H13ClN2O3
- Formula Weight
- 256.69
- MOL File
- 868736-42-9.mol
More
Less
tert-Butyl (4-chloro-3-formylpyridin-2-yl)carbamate Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- Appearance
- Off-white to light yellow Solid
More
Less
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- ADE000812
- Product name
- tert-Butyl 4-chloro-3-formylpyridin-2-ylcarbamate
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 1 g
- Price
- $817
- Updated
- 2025/07/31
SynQuest Laboratories
- Product number
- 4H51-5-10
- Product name
- tert-Butyl N-(4-chloro-3-formylpyridin-2-yl)carbamate
- Packaging
- 250mg
- Price
- $129
- Updated
- 2021/12/16
AK Scientific
- Product number
- V8241
- Product name
- tert-Butyl4-chloro-3-formylpyridin-2-ylcarbamate
- Packaging
- 250mg
- Price
- $157
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 055596
- Product name
- tert-Butyl 4-chloro-3-formylpyridin-2-ylcarbamate
- Packaging
- 100mg
- Price
- $237
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0369967
- Product name
- TERT-BUTYL-(4-CHLORO-3-FORMYLPYRIDIN-2-YL)CARBAMATE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $279.3
- Updated
- 2021/12/16
More
Less
tert-Butyl (4-chloro-3-formylpyridin-2-yl)carbamate Chemical Properties,Usage,Production
Synthesis
130721-78-7
68-12-2
868736-42-9
The general procedure for the synthesis of tert-butyl 4-chloro-3-formylpyridine-2-carbamate from 2-BOC-amino-4-chloropyridine and N,N-dimethylformamide was as follows: firstly, tert-butyl (4-chloropyridin-2-yl)carbamate (15.0 g, 65.59 mmol) was dissolved in THF (300 mL) and the solution was cooled down to -78 °C. Under stirring, nBuLi (55.1 mL, 2.50 M, 137.7 mmol) was slowly added dropwise over 20 min. The reaction mixture was continued stirring at -78 °C for 30 min to form a pale yellow solution. Subsequently, DMF (15.1 mL, 196.8 mmol) was added dropwise over 5 minutes and stirring was continued at -78 °C for 1 hour. Upon completion of the reaction, the reaction was quenched with MeOH (2 eq.) and subsequently concentrated. After addition of HCl (16 mL), the mixture was concentrated again. The residue was suspended in EtOAc and washed sequentially with 5% NaHCO3 solution and brine before evaporating the solvent. The crude product was suspended in hexane (100 mL) and the precipitate was collected by filtration to afford the target intermediate tert-butyl 4-chloro-3-formylpyridine-2-carbamate (12.8 g, 76% yield) as a white solid.
References
[1] Patent: US2012/190654, 2012, A1. Location in patent: Page/Page column 12
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 8, p. 3330 - 3348
[3] Patent: WO2018/170284, 2018, A1. Location in patent: Paragraph 00263
[4] Journal of Medicinal Chemistry, 2009, vol. 52, # 5, p. 1251 - 1254
[5] Patent: US2013/237555, 2013, A1. Location in patent: Paragraph 0168
tert-Butyl (4-chloro-3-formylpyridin-2-yl)carbamate Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
tert-Butyl (4-chloro-3-formylpyridin-2-yl)carbamate Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 28-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 510
- Advantage
- 57
- Tel
- 15921303235
- Fax
- QQ489466966
- sales@synthfine.com
- Country
- China
- ProdList
- 1042
- Advantage
- 58
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 021-58111238 18930958102
- Fax
- 021-58111238
- sales@taifupharm.com
- Country
- China
- ProdList
- 509
- Advantage
- 55
- Tel
- 15121041756
- xingui2022@126.com
- Country
- China
- ProdList
- 9979
- Advantage
- 58
- Tel
- 13817873692
- Fax
- 021-31329586
- mkt@boynerspharm.com
- Country
- China
- ProdList
- 1707
- Advantage
- 55
- Tel
- 028-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 7218
- Advantage
- 58
- Tel
- 0510-83583050 13771062561
- Fax
- 0510-83583039
- willsun@peptide-search.com
- Country
- China
- ProdList
- 6716
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-58361106-805 15951641583
- Fax
- 025-58361106-806
- zhao.xu@njpeptide.com
- Country
- China
- ProdList
- 9979
- Advantage
- 55
- Tel
- 0530-+86-530-529 6766，+86-15666160102 15666160102
- Fax
- 0530-529 6766
- info@chuangli-chem.com
- Country
- China
- ProdList
- 836
- Advantage
- 55
- Tel
- 13918479294
- Fax
- -
- xiebenfa@163.com
- Country
- China
- ProdList
- 4090
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 021-58581007 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12878
- Advantage
- 58
- Tel
- 0751-2815688 13927872512
- Fax
- 0751-8963795
- 3007421951@qq.com
- Country
- China
- ProdList
- 9939
- Advantage
- 58
- Tel
- 021-61263370 18901917034
- xingli@glbiochem.com
- Country
- China
- ProdList
- 5637
- Advantage
- 58
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Country
- China
- ProdList
- 19103
- Advantage
- 58
- Tel
- 021-61263377 15023907684
- Fax
- 021-61263399
- 15800684150@163.com
- Country
- China
- ProdList
- 8131
- Advantage
- 58
- Tel
- +86-0551-65418684 +8618949823763
- Fax
- 0086-551-65418684
- sales@tnjchem.com
- Country
- China
- ProdList
- 25356
- Advantage
- 58
- Tel
- +86-0571-81612335 +8613336028439
- sales@nextpeptide.com
- Country
- China
- ProdList
- 19908
- Advantage
- 58
- Tel
- +8615056975894
- Fax
- 86-0551-62678551
- shawn@hirisunpharm.com
- Country
- CHINA
- ProdList
- 9911
- Advantage
- 58
- Tel
- +86-0571-85134551
- Fax
- 008657185134895
- sales@afinechem.com
- Country
- China
- ProdList
- 15109
- Advantage
- 58
- Tel
- 0371-63284658 18135795563
- Fax
- QQ:2885349392
- 2885349392@qq.com
- Country
- China
- ProdList
- 9992
- Advantage
- 58
- Tel
- 021-61263375 18168859245
- Country
- China
- ProdList
- 5958
- Advantage
- 58
- Tel
- +86-023-6139-8061 +86-86-13650506873
- sales@chemdad.com
- Country
- China
- ProdList
- 39927
- Advantage
- 58
- Tel
- 13771048682 15061806929
- alice@mimotopes.cn
- Country
- China
- ProdList
- 5796
- Advantage
- 58
- Tel
- 18221292452
- fannieliu@glschina.com
- Country
- China
- ProdList
- 6798
- Advantage
- 58
- Tel
- 15151934985
- sales@yingsapharm.com
- Country
- China
- ProdList
- 5181
- Advantage
- 58
- Tel
- 18217475093
- 1615396342@qq.com
- Country
- China
- ProdList
- 4309
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49312
- Advantage
- 58
- Tel
- 021-61263455 13167021076
- amy@glschina.com
- Country
- China
- ProdList
- 9736
- Advantage
- 58
- Tel
- 650-6922368
- sales@achemblock.com
- Country
- China
- ProdList
- 2992
- Advantage
- 58
- Tel
- 15727060112
- yutianchun2007@126.com
- Country
- China
- ProdList
- 9814
- Advantage
- 58
- Tel
- 13564747822
- Fax
- QQ774046800
- 669027880@qq.com
- Country
- China
- ProdList
- 946
- Advantage
- 58
- Tel
- 0512-85667806 18551283436
- Fax
- 0512-85667816
- sales@sanbem.com
- Country
- China
- ProdList
- 3018
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 15895968936
- Fax
- qq 1018762393
- 1018762393@qq.com
- Country
- China
- ProdList
- 9999
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44119
- Advantage
- 58
- Tel
- 15658004993
- 1900830611@qq.com
- Country
- China
- ProdList
- 980
- Advantage
- 58
- Tel
- 2383948258 19172820304
- 2383948258@qq.com
- Country
- China
- ProdList
- 12987
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 18130062233
- 3362556465@qq.com
- Country
- China
- ProdList
- 8100
- Advantage
- 58
- Tel
- 13000000000
- Fax
- jinoupharma@163
- jinoupharma@163.com
- Country
- China
- ProdList
- 11721
- Advantage
- 58
- Tel
- 4000255188
- Fax
- 025 86918232
- sales_china@pharmablock.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- 18992018580 18165105898
- Fax
- QQ:1617857088
- 13608210612@163.com
- Country
- China
- ProdList
- 2985
- Advantage
- 58
- Tel
- +86-0571-86912261 +86-15658003402
- Fax
- 311113
- sales@newcanbio.com
- Country
- China
- ProdList
- 1391
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39653
- Advantage
- 58