N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride
- Product Name
- N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride
- CAS No.
- 917369-31-4
- Chemical Name
- N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride
- Synonyms
- Azixa;EP-128495;MPC 6827 hydrochloride;Verubulin hydrochloride;Verubulin hydrochloride (MPC-6827 hydrochloride);N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine hydrochloride;N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride;MPC-6827,Microtubule/Tubulin,Verubulin,Verubulin hydrochloride,MPC 6827,inhibit,MPC6827,Inhibitor
- CBNumber
- CB52510098
- Molecular Formula
- C17H17N3O.HCl
- Formula Weight
- 315.79732
- MOL File
- 917369-31-4.mol
N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride Property
- storage temp.
- Desiccate at RT
- solubility
- ≥10.55 mg/mL in DMSO; ≥28.1 mg/mL in EtOH; ≥5 mg/mL in H2O
- form
- Powder
N-Bromosuccinimide Price
- Product number
- 5231
- Product name
- MPC6827hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $210
- Updated
- 2021/12/16
- Product number
- 5231
- Product name
- MPC6827hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $862
- Updated
- 2021/12/16
- Product number
- 255894
- Product name
- MPC 6827 hydrochloride
- Packaging
- 10mg
- Price
- $466
- Updated
- 2021/12/16
- Product number
- M326508
- Product name
- MPC6827Hydrochloride
- Packaging
- 2.5mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-0003074
- Product name
- Verubulinhydrochloride
- Purity
- 98.27%
- Packaging
- 1mg
- Price
- $130
- Updated
- 2021/12/16
N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride Chemical Properties,Usage,Production
Uses
MPC 6827 Hydrochloride is a microtubule destabilizing agent which may be used in the treatment of patients with cancer.
Biological Activity
mpc-6827 (azixa) is a small-molecule microtubule-destabilizing agent that binds to the same (or nearby) sites on β-tubulin as colchicine.[1]tubulin is a heterodimer consisting of an αand βmonomer, it can be covalently labeled with [3h] colchicine by near uv irradiation. most of the label appears in β tubulin. colchicine binds to tubulin with a stoichiometry of one and inhibits microtubule assembly substoichiometrically. colchicine binding to tubulin exhibits pseudoirreversible kinetics; it displays a fast step followed by a slow step involving conformational changes of both ligand and tubulin. the tubulin, in turn, promotes fluorescence characteristic of the tropolone moiety of colchicine. [2]mpc-6827 is a small-molecule microtubule-destabilizing agent that causes mitotic arrest and cell death. mpc-6827 interfere with microtubule dynamics, leading to arrest of dividing cells in the g2-m phase of the cell cycle, which eventually results in apoptotic cell death.[1]
in vivo
mpc-6827 significantly inhibits the growth of various subcutaneously implanted tumor lines. mpc-6827 has also been shown to be a vascular-disrupting agent (vda) in a human ovarian carcinoma xenograft model. it also has shown synergism with carboplatin in a mouse xenograft model. furthermore, mpc-6827 has been shown to inhibit the growth of human glioblastoma tumor cell line (d-54) implanted intracranially in athymic nude mice. [1]
storage
Desiccate at RT
References
[1] tsimberidou am1, akerley w, schabel mc, etal. , phase i
N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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