N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride

Product Name: N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride
CAS No.: 917369-31-4
Chemical Name: N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride
Synonyms: Azixa;EP-128495;MPC 6827 hydrochloride;Verubulin hydrochloride;Verubulin hydrochloride (MPC-6827 hydrochloride);N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine hydrochloride;N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride;MPC-6827,Microtubule/Tubulin,Verubulin,Verubulin hydrochloride,MPC 6827,inhibit,MPC6827,Inhibitor
CBNumber: CB52510098
Molecular Formula: C17H17N3O.HCl
Formula Weight: 315.79732
MOL File: 917369-31-4.mol

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N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride Property

storage temp.: Desiccate at RT
solubility: ≥10.55 mg/mL in DMSO; ≥28.1 mg/mL in EtOH; ≥5 mg/mL in H2O
form: Powder
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 5231
Product name: MPC6827hydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $210
Updated: 2021/12/16

Tocris

Product number: 5231
Product name: MPC6827hydrochloride
Purity: ≥98%(HPLC)
Packaging: 50
Price: $862
Updated: 2021/12/16

Usbiological

Product number: 255894
Product name: MPC 6827 hydrochloride
Packaging: 10mg
Price: $466
Updated: 2021/12/16

TRC

Product number: M326508
Product name: MPC6827Hydrochloride
Packaging: 2.5mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-0003074
Product name: Verubulinhydrochloride
Purity: 98.27%
Packaging: 1mg
Price: $130
Updated: 2021/12/16

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N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride Chemical Properties,Usage,Production

Uses

MPC 6827 Hydrochloride is a microtubule destabilizing agent which may be used in the treatment of patients with cancer.

Biological Activity

mpc-6827 (azixa) is a small-molecule microtubule-destabilizing agent that binds to the same (or nearby) sites on β-tubulin as colchicine.[1]tubulin is a heterodimer consisting of an αand βmonomer, it can be covalently labeled with [3h] colchicine by near uv irradiation. most of the label appears in β tubulin. colchicine binds to tubulin with a stoichiometry of one and inhibits microtubule assembly substoichiometrically. colchicine binding to tubulin exhibits pseudoirreversible kinetics; it displays a fast step followed by a slow step involving conformational changes of both ligand and tubulin. the tubulin, in turn, promotes fluorescence characteristic of the tropolone moiety of colchicine. [2]mpc-6827 is a small-molecule microtubule-destabilizing agent that causes mitotic arrest and cell death. mpc-6827 interfere with microtubule dynamics, leading to arrest of dividing cells in the g2-m phase of the cell cycle, which eventually results in apoptotic cell death.[1]

in vivo

mpc-6827 significantly inhibits the growth of various subcutaneously implanted tumor lines. mpc-6827 has also been shown to be a vascular-disrupting agent (vda) in a human ovarian carcinoma xenograft model. it also has shown synergism with carboplatin in a mouse xenograft model. furthermore, mpc-6827 has been shown to inhibit the growth of human glioblastoma tumor cell line (d-54) implanted intracranially in athymic nude mice. [1]

storage

Desiccate at RT

References

[1] tsimberidou am1, akerley w, schabel mc, etal. , phase i

N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride Suppliers

China 25 United Kingdom 1 United States 9 Global 35

TargetMol Chemicals Inc.

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917369-31-4, N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochlorideRelated Search:

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N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride

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917369-31-4