ChemicalBook > CAS DataBase List > 6-Fluoro-3H-isobenzofuran-1-one
6-Fluoro-3H-isobenzofuran-1-one
- Product Name
- 6-Fluoro-3H-isobenzofuran-1-one
- CAS No.
- 23932-84-5
- Chemical Name
- 6-Fluoro-3H-isobenzofuran-1-one
- Synonyms
- 6-Fluorophthalide;6-FLUORO-3H-2-BENZOFURAN-1-ONE;6-fluoro-2-benzofuran-1(3H)-one;6-Fluoroisobenzofuran-1(3H)-one;6-Fluoro-3H-isobenzofuran-1-one;1(3H)-Isobenzofuranone, 6-fluoro-;6-fluoro-1,3-dihydro-2-benzofuran-1-one
- CBNumber
- CB52512087
- Molecular Formula
- C8H5FO2
- Formula Weight
- 152.12
- MOL File
- 23932-84-5.mol
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6-Fluoro-3H-isobenzofuran-1-one Property
- Melting point:
- 111.5-112 °C
- Boiling point:
- 306.6±42.0 °C(Predicted)
- Density
- 1.379±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
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Safety
- HS Code
- 2932209090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- F593378
- Product name
- 6-fluoro-3H-2-benzofuran-1-one
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC500778
- Product name
- 6-Fluorophthalide
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 2H25-3-19
- Product name
- 6-Fluorophthalide
- Purity
- 95.0%
- Packaging
- 250mg
- Price
- $200
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 096597
- Product name
- 6-Fluoroisobenzofuran-1(3H)-one
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $378
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 096597
- Product name
- 6-Fluoroisobenzofuran-1(3H)-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $840
- Updated
- 2021/12/16
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6-Fluoro-3H-isobenzofuran-1-one Chemical Properties,Usage,Production
Synthesis
138786-65-9
23932-84-5
General procedure for the synthesis of 6-fluoro-1(3H)-isobenzofuranone from methyl 2-(bromomethyl)-5-fluorobenzoate: 1. to a solvent mixture of 1,4-dioxane (30 mL) and water (30.0 mL) was added methyl 2-(bromomethyl)-5-fluorobenzoate (0.750 g, 3.04 mmol) and calcium carbonate (1.823 g, 18.21 mmol) and the mixture was heated and refluxed for 2.5 hours. 2. After completion of the reaction, the insoluble material was removed by filtration. 3. The filtrate was concentrated under vacuum and subsequently extracted with dichloromethane (4 x 30 mL). 4. The organic extracts were combined and dried with anhydrous magnesium sulfate. 5. The solvent was removed under vacuum to afford 6-fluoro-1(3H)-isobenzofuranone (0.423 g, 2.78 mmol, 92% yield) as a white solid.
References
[1] Patent: WO2011/159857, 2011, A1. Location in patent: Page/Page column 90-91
6-Fluoro-3H-isobenzofuran-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
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