Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate
- Product Name
- Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate
- CAS No.
- 1215205-50-7
- Chemical Name
- Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate
- Synonyms
- EOS-60373;Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate;ethyl1-(4-bromophenyl)cyclopropane-1-carboxylate;1-(4-Bromo-phenyl)-cyclopropanecarboxylic acid ethyl ester;Cyclopropanecarboxylic acid, 1-(4-bromophenyl)-, ethyl ester
- CBNumber
- CB52513554
- Molecular Formula
- C12H13BrO2
- Formula Weight
- 269.13
- MOL File
- 1215205-50-7.mol
Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate Property
- Boiling point:
- 306.5±35.0 °C(Predicted)
- Density
- 1.445±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light yellow to brown Solid-Liquid Mixture
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E900895
- Product name
- Ethyl1-(4-bromophenyl)cyclopropanecarboxylate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- HCH0368660
- Product name
- ETHYL-1-(4-BROMOPHENYL)CYCLOPROPANECARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.56
- Updated
- 2021/12/16
- Product number
- Z8358
- Product name
- Ethyl1-(4-bromophenyl)cyclopropanecarboxylate
- Packaging
- 1g
- Price
- $169
- Updated
- 2021/12/16
- Product number
- 153525
- Product name
- Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate
- Purity
- 95%
- Packaging
- 10g
- Price
- $1480
- Updated
- 2021/12/16
- Product number
- 153525
- Product name
- Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate
- Purity
- 95%
- Packaging
- 25g
- Price
- $2590
- Updated
- 2021/12/16
Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate Chemical Properties,Usage,Production
Synthesis
14062-25-0
106-93-4
1215205-50-7
Example 14A Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate was synthesized as follows: first, 1.45 g (36.2 mmol) of sodium hydroxide (60% mineral oil dispersion) was suspended in 100 mL of anhydrous DMF. Subsequently, a mixture of 4.0 g (16.5 mmol) of ethyl p-bromophenylacetate with 6.5 g (34.6 mmol) of 1,2-dibromoethane was dissolved in 50 mL of anhydrous THF and this solution was added slowly and dropwise to the sodium hydride suspension. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate and washed sequentially with water and saturated sodium chloride solution. The organic phase was separated, dried with anhydrous magnesium sulfate, filtered and the filtrate concentrated. The residue was purified by preparative HPLC [column: Reprosil C18, 10 μm, 250 mm × 40 mm; mobile phase: 30% methanol/70% water to 100% methanol gradient elution, run time 25 min]. After HPLC analysis, the fractions containing the target product were combined and concentrated to give 1.15 g (26% yield) of the target product as a liquid. The product was characterized by GC-MS [Method 5] and 1H-NMR (400 MHz, DMSO-d6): GC-MS retention time Rt = 5.45 min; MS (ESIpos): m/z = 268/270 [M+]; 1H-NMR δ (ppm): 1.09 (t, 3H), 1.16-1.20 (m, 2H), 1.46-1.50 (m, 2H) 1.46-1.50 (m, 2H), 4.02 (q, 2H), 7.26-7.31 (m, 2H), 7.47-7.51 (m, 2H).
References
[1] Patent: US2016/318866, 2016, A1. Location in patent: Paragraph 0642; 0643; 06444; 0645
Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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