1,2,3,4-tetrahydro-8-Quinolinecarbonitrile
- Product Name
- 1,2,3,4-tetrahydro-8-Quinolinecarbonitrile
- CAS No.
- 50741-37-2
- Chemical Name
- 1,2,3,4-tetrahydro-8-Quinolinecarbonitrile
- Synonyms
- 1,2,3,4-tetrahydroquinoline-8-carbonitrile;1,2,3,4-tetrahydro-8-Quinolinecarbonitrile;8-Quinolinecarbonitrile, 1,2,3,4-tetrahydro-
- CBNumber
- CB52514061
- Molecular Formula
- C10H10N2
- Formula Weight
- 158.2
- MOL File
- 50741-37-2.mol
1,2,3,4-tetrahydro-8-Quinolinecarbonitrile Property
- Boiling point:
- 323.6±31.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.62±0.20(Predicted)
- Appearance
- Light yellow to green yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P000359364
- Product name
- 1,2,3,4-Tetrahydroquinoline-8-carbonitrile
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $124
- Updated
- 2021/12/16
- Product number
- 7008AB
- Product name
- 1,2,3,4-Tetrahydroquinoline-8-carbonitrile
- Packaging
- 100mg
- Price
- $192
- Updated
- 2021/12/16
- Product number
- P000359364
- Product name
- 1,2,3,4-Tetrahydroquinoline-8-carbonitrile
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $217
- Updated
- 2021/12/16
- Product number
- 7008AB
- Product name
- 1,2,3,4-Tetrahydroquinoline-8-carbonitrile
- Packaging
- 250mg
- Price
- $262
- Updated
- 2021/12/16
- Product number
- P000359364
- Product name
- 1,2,3,4-Tetrahydroquinoline-8-carbonitrile
- Purity
- 95+%
- Packaging
- 1g
- Price
- $541
- Updated
- 2021/12/16
1,2,3,4-tetrahydro-8-Quinolinecarbonitrile Chemical Properties,Usage,Production
Synthesis
635-46-1
545-06-2
50741-37-2
Under cooling conditions in an ice bath, 1.33 g of 1,2,3,4-tetrahydroquinoline was dissolved in 10 mL of toluene, followed by the slow addition of 5.5 mL of a 2.02 M toluene solution of boron trichloride. The reaction mixture was placed in an oil bath and refluxed for 1 hour. Upon completion of the reaction, the toluene solvent was removed by atmospheric pressure distillation. The resulting residue was mixed with 2 mL of trichloroacetonitrile and heated in an oil bath at 60°C to 62°C for 20 hours. The reaction mixture was cooled, dissolved in 20 ml of dichloromethane and slowly poured into 40 ml of methanol solution containing 9.1 g of potassium carbonate under cooling in an ice bath. This mixture was refluxed in an oil bath for 1 hour and subsequently filtered to remove insoluble impurities. The filtrate was concentrated and subjected to liquid-liquid partition extraction with water and dichloromethane. The dichloromethane layer was washed with dilute hydrochloric acid, dried over anhydrous magnesium sulfate and subsequently concentrated to remove the solvent. The resulting crude product (1.53 g) was purified by Lobar column chromatography employing dichloromethane as eluent and the target fractions were collected. The product was further recrystallized using a mixed ether-hexane solvent, resulting in 1.07 g of 8-cyano-1,2,3,4-tetrahydroquinoline crystals with a melting point of 75°C to 76°C in 68% yield.
References
[1] Patent: US4774331, 1988, A
[2] Synthetic Communications, 1990, vol. 20, # 1, p. 71 - 84
1,2,3,4-tetrahydro-8-Quinolinecarbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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