7-amino-4-methyl-1H-indole-3-carbonitrile
- Product Name
- 7-amino-4-methyl-1H-indole-3-carbonitrile
- CAS No.
- 289483-87-0
- Chemical Name
- 7-amino-4-methyl-1H-indole-3-carbonitrile
- Synonyms
- 7-Amino-3cyano-4-methyl-1H-indole;7-amino-4-methyl-1H-indole-3-carbonitrile;7-Amino-4-methyl-1H-indole-4-carbonitrile;1H-Indole-3-carbonitrile, 7-aMino-4-Methyl-;7-amino-4-methyl-1H-indole-3-carbonitrile hydrochloride
- CBNumber
- CB52515008
- Molecular Formula
- C10H9N3
- Formula Weight
- 171.2
- MOL File
- 289483-87-0.mol
7-amino-4-methyl-1H-indole-3-carbonitrile Property
- Boiling point:
- 441.2±40.0 °C(Predicted)
- Density
- 1.28
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 15.65±0.30(Predicted)
- Appearance
- Gray to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CHM0157131
- Product name
- 7-AMINO-4-METHYL-1H-INDOLE-3-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.97
- Updated
- 2021/12/16
- Product number
- W5155
- Product name
- 7-Amino-4-methyl-1H-indole-3-carbonitrile
- Packaging
- 100mg
- Price
- $335
- Updated
- 2021/12/16
- Product number
- FA155992
- Product name
- 7-Amino-4-methyl-1H-indole-3-carbonitrile
- Packaging
- 1g
- Price
- $6000
- Updated
- 2021/12/16
- Product number
- P2809
- Product name
- 7-amino-4-methyl-1H-Indole-3-carbonitrile
- Purity
- 97.00%
- Packaging
- 25G
- Price
- $7570
- Updated
- 2021/12/16
- Product number
- A143900
- Product name
- 7-Amino-4-methyl-1H-indole-3-carbonitrile
- Purity
- 95%
- Packaging
- 50mg
- Price
- $93
- Updated
- 2021/12/16
7-amino-4-methyl-1H-indole-3-carbonitrile Chemical Properties,Usage,Production
Synthesis
289483-82-5
289483-87-0
The general procedure for the synthesis of 7-amino-4-methyl-1H-indole-3-carbonitrile from 4-methyl-7-nitro-1H-indole-3-carbonitrile is as follows: the method of reference Example 3A; synthesis of 7-amino-3-cyano-4-methyl-1H-indole; 12.6 g (62.6 mmol) of 3-cyano-4-methyl-7-nitro-1H- indole was suspended in a solvent mixture of 100 mL of tetrahydrofuran and 100 mL of methanol. The hydrogenation reaction was carried out at room temperature and 3 atm hydrogen pressure with the addition of 430 mg (1.87 mmol) of platinum oxide as catalyst. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to dryness. A mixed solvent of tert-butyl methyl ether and hexane was added to the residue and the precipitated crystals were collected by filtration to give 10.7 g of 7-amino-4-methyl-1H-indole-3-carbonitrile (yield: 99.8%). The product was characterized by 1H-NMR (DMSO-d6): δ (ppm) 2.47 (3H, s), 5.07 (2H, s), 6.34 (1H, d, J = 7.6 Hz), 6.64 (1H, d, J = 7.6 Hz), 8.10 (1H, s), 11.70 (1H, br s).
References
[1] Patent: US2007/37854, 2007, A1. Location in patent: Page/Page column 6
[2] Patent: EP1666463, 2006, A1. Location in patent: Page/Page column 10
[3] Patent: US2007/37854, 2007, A1. Location in patent: Page/Page column 4
7-amino-4-methyl-1H-indole-3-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-amino-4-methyl-1H-indole-3-carbonitrile manufacturers
- Product
- 7-amino-4-methyl-1H-indole-3-carbonitrile 289483-87-0
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02