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SB271046

Product Name
SB271046
CAS No.
209481-20-9
Chemical Name
SB271046
Synonyms
CS-1869;SB 737050;SB 271046;SB271046 HCL;SB271046 USP/EP/BP;SB 271046 (SB-271046A);SB 271046 hydrochloride;SB271046 5-HT6 receptor antagonist orally active SB-271046;Benzo[b]thiophene-2-sulfonamide, 5-chloro-N-[4-methoxy-3-(1-pipe;5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide
CBNumber
CB52515846
Molecular Formula
C20H22ClN3O3S2
Formula Weight
451.99
MOL File
209481-20-9.mol
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SB271046 Property

Melting point:
240-241℃ (DEC.)
Boiling point:
664.3±65.0 °C(Predicted)
Density 
1.400
storage temp. 
Desiccate at RT
solubility 
Soluble in DMSO > 10 mM
form 
Powder
pka
7.61±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris
Product number
3368
Product name
SB271046hydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$225
Updated
2021/12/16
Tocris
Product number
3368
Product name
SB271046hydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$943
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0006978
Product name
SB-271046
Purity
95.00%
Packaging
10MG
Price
$286.65
Updated
2021/12/16
Crysdot
Product number
CD41001607
Product name
5-Chloro-N-(4-methoxy-3-(piperazin-1-yl)phenyl)-3-methylbenzo[b]thiophene-2-sulfonamide
Purity
97%
Packaging
100mg
Price
$580
Updated
2021/12/16
Alichem
Product number
209481209
Product name
5-Chloro-N-(4-methoxy-3-(piperazin-1-yl)phenyl)-3-methylbenzo[b]thiophene-2-sulfonamide
Packaging
100mg
Price
$614.8
Updated
2021/12/16
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SB271046 Chemical Properties,Usage,Production

Uses

SB 271046 is a potent, selective and orally active 5-HT6 receptor antagonist with a pKi of 8.92-9.09. SB 271046 show >200-fold selective for the 5-HT6 receptor over other receptors, binding sites and ion channels. SB 271046 has anticonvulsant activity[1].

in vivo

SB 271046 produces an increase in seizure threshold over a wide-dose range in the rat maximal electroshock seizure threshold (MEST) test, with a minimum effective dose of ?0.1?mg/kg p.o. and maximum effect at 4?h post-dose. The level of anticonvulsant activity achieved correlated well with the blood concentrations of SB 271046 (EC50 of 0.16?μM) and brain concentrations of 0.01-0.04?μM at Cmax[1].

IC 50

5-HT6 Receptor: 8.92-9.09 (pKi)

storage

room temperature (desiccate)

References

[1] C Routledge, et al. Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist. Br J Pharmacol. 2000 Aug;130(7):1606-12. DOI:10.1038/sj.bjp.0703457

SB271046 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB271046 Suppliers

China 58 The Netherlands 1 United Kingdom 2 United States 7 Global 68
Axon Medchem BV
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
The Netherlands
ProdList
477
Advantage
30

209481-20-9, SB271046Related Search:


  • 5-chloro-N-(4-methoxy-3-(piperazin-1-yl)phenyl)-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride
  • 5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methyl-benzo[b]thiophen-2-sulfonamide hydrochloride
  • SB 271046 hydrochloride
  • 5-Chloro-3-Methyl-Benzo[b]Thiophene-2-Carboxylic Acid (4-Methoxy-3-Piperazin-1-yl-Phenyl)-AMide H
  • 1. 5-Chloro-3-Methyl-Benzo[b]Thiophene-2-Carboxylic Acid (4-Methoxy-3-Piperazin-1-yl-Phenyl)-AMide H
  • SB 271046
  • 5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide
  • SB 737050
  • CS-1869
  • Benzo[b]thiophene-2-sulfonaMide, 5-chloro-N-[4-Methoxy-3-(1-piperazinyl)phenyl]-3-Methyl-
  • SB271046 hydrochloride 5-Chloro-N-[4-Methoxy-3-(1-piperazinyl)phenyl]-3-Methylbenzo[b]thiophene-2-sulfonaMide
  • 5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide SB 271046
  • SB271046 HCL
  • Benzo[b]thiophene-2-sulfonamide, 5-chloro-N-[4-methoxy-3-(1-pipe
  • 5-Chloro-N-(4-methoxy-3-(piperazin-1-yl)phenyl)-3-methylbenzo[b]thiophene-2-sulfonamide
  • SB271046 USP/EP/BP
  • SB 271046 (SB-271046A)
  • SB271046 5-HT6 receptor antagonist orally active SB-271046
  • SB 271046 hydrochloride/5-chloro-N-(4-methoxy-3-(piperazin-1-yl)phenyl)-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride
  • 209481-20-9
  • C20H22CIN3O3S2HCl
  • Inhibitors