ChemicalBook > CAS DataBase List > LX-4211

LX-4211

Product Name
LX-4211
CAS No.
1018899-04-1
Chemical Name
LX-4211
Synonyms
Sotagliflozin;β-L-Xylopyranoside,methyl5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-,(5S)-;(5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-beta-L-xylopyranoside Sotagliflozin LP 802034;LX421;CS-1853;LX-4211;SOTA-009;LP 802034;EOS-61381;LX4211/LX-4211
CBNumber
CB52516025
Molecular Formula
C21H25ClO5S
Formula Weight
424.94
MOL File
1018899-04-1.mol
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LX-4211 Property

Boiling point:
607.9±55.0 °C(Predicted)
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:84.0(Max Conc. mg/mL);197.67(Max Conc. mM)
Ethanol:17.0(Max Conc. mg/mL);40.01(Max Conc. mM)
pka
12.87±0.70(Predicted)
form 
Powder
color 
White to off-white
optical activity
35.7°(C=0.01g/mL, CHCL3, 20°C, 589nm)
InChIKey
QKDRXGFQVGOQKS-WFCPIQDQNA-N
SMILES
[C@@H]1(C2=CC=C(Cl)C(CC3=CC=C(OCC)C=C3)=C2)O[C@H](SC)[C@@H](O)[C@H](O)[C@H]1O |&1:0,19,22,24,26,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19141
Product name
Sotagliflozin
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
19141
Product name
Sotagliflozin
Purity
≥98%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
19141
Product name
Sotagliflozin
Purity
≥98%
Packaging
10mg
Price
$283
Updated
2024/03/01
Cayman Chemical
Product number
19141
Product name
Sotagliflozin
Purity
≥98%
Packaging
25mg
Price
$573
Updated
2024/03/01
ApexBio Technology
Product number
A3567
Product name
LX-4211
Packaging
5mg
Price
$165
Updated
2021/12/16
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LX-4211 Chemical Properties,Usage,Production

Uses

Sotagliflozin is used for the treatment of patients with type 1 diabetes mellitus.

Clinical Use

Two of the current SGLT-2 inhibitors (canagliflozin and LX-4211) have effects on SGLT-1. LX-4211 is a dual SGLT1/2 inhibitor and higher doses of canagliflozin transiently inhibit SGLT-1 in the gut due to high canagliflozin concentrations within the intestinal lumen during the period of drug absorption.

Synthesis

Sotagliflozin is a dual SGLT-1/SGLT-2 inhibitor which is currently under development by Lexicon Pharmaceuticals (phase III). It follows a similar strategy to ertugliflozin, i.e. aryl addition on an acyclic precursor. The synthesis starts from L-xylose 53, and the aryl moiety (same aryl moiety as for dapagliflozin) is introduced on an amide derivative (morpholine amide 54) via Grignard addition. A subsequent transformation leads to the sotagliflozin (Scheme 10). The overall yield of the synthesis is around 30%.

Sotagliflozin synthesis

IC 50

SGLT1; SGLT2

LX-4211 Preparation Products And Raw materials

Raw materials

Preparation Products

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LX-4211 Suppliers

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View Lastest Price from LX-4211 manufacturers

Wuhan JiyunZen Tech Co., Ltd.
Product
LX-4211 1018899-04-1
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-06-05
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
LX-4211 1018899-04-1
Price
US $999.00-900.00/kg
Min. Order
0.0010000000474974513kg
Purity
99%
Supply Ability
5000
Release date
2024-08-08
Shaanxi Dideu New Materials Co. Ltd
Product
LX-4211 1018899-04-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2024-11-13

1018899-04-1, LX-4211Related Search:

Dapagliflozin Empagliflozin D-Glucitol, 1,5-dideoxy-1,5-epithio-1-C-[5-[(4-ethoxyphenyl)Methyl]-2-Methoxy-4-Methylphenyl]-, (1S)- Tofogliflozin Ipragliflozin Canagliflozin

  • (2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-ethoxybenzyl)phenyl]-6-(methylsulfanyl)tetrahydro-2-H-pyran-3,4,5-triol
  • CS-1853
  • LX4211; LX 4211; LX4211; LX 4211
  • LX-4211
  • (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(Methylthio)tetrahydro-2H-pyran-3,4,5-triol
  • (5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-1-thio-beta-L-xylopyranoside
  • Sotagliflozin
  • LX4211/LX-4211
  • LP 802034
  • (5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-beta-L-xylopyranoside Sotagliflozin LP 802034
  • LX4211 - L10525
  • LX-4211 (sotagliflozin)
  • LX-4211, >=98%
  • Zabofloxacin Hydrochloride
  • EOS-61381
  • (2S,3R,4R,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyloxane-3,4,5-triol
  • SOTA-009
  • LX421
  • Sotagliflozin lx4211
  • LX4211, 98%, a potent dual SGLT2/1 inhibitor
  • Sotagliflozin, must
  • LX4211/Sotagliflozin-API
  • β-L-Xylopyranoside, methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-, (5S)-
  • Sotagliflozin,0.99
  • β-L-Xylopyranoside,methyl5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-,(5S)-
  • UNII-6B4ZBS263Y
  • Sotagliflozin,LX-4211, LP-802034, LX4211, LP802034
  • LX-4211|||LP-802034
  • Bifeprunox Impurity 42
  • Sotagliflozin, 10 mM in DMSO
  • 1018899-04-1
  • C21H25O5ClS
  • C21H25ClO5S