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6-Methyl-1,2-benzisoxazol-3(2H)-one

Product Name
6-Methyl-1,2-benzisoxazol-3(2H)-one
CAS No.
66571-26-4
Chemical Name
6-Methyl-1,2-benzisoxazol-3(2H)-one
Synonyms
6-Methyl-1,2-benzoxazol-3-one;6-Methyl-1,2-benzisoxazol-3-ol;6-Methylbenzo[d]isoxazol-3(2H);6-Methylbenzo[d]isoxazol-3(2H)-one;6-Methyl-1,2-benzisoxazol-3(2H)-one;1,2-Benzisoxazol-3(2H)-one, 6-methyl-
CBNumber
CB52516333
Molecular Formula
C8H7NO2
Formula Weight
149.15
MOL File
66571-26-4.mol
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6-Methyl-1,2-benzisoxazol-3(2H)-one Property

Melting point:
148-150 °C
Density 
1.259±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
13.66±0.20(Predicted)
Appearance
White to light yellow Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific
Product number
Z5011
Product name
6-Methylbenzo[d]isoxazol-3(2H)-one
Packaging
100mg
Price
$112
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0391447
Product name
6-METHYLBENZO[D]ISOXAZOL-3(2H)-ONE
Purity
95.00%
Packaging
5MG
Price
$503.99
Updated
2021/12/16
Matrix Scientific
Product number
119523
Product name
6-Methylbenzo[d]isoxazol-3(2H)-one
Purity
95+%
Packaging
250mg
Price
$612
Updated
2021/12/16
Matrix Scientific
Product number
119523
Product name
6-Methylbenzo[d]isoxazol-3(2H)-one
Purity
95+%
Packaging
1g
Price
$1530
Updated
2021/12/16
Advanced Chemicals Intermediatesced Chemicals Intermediates
Product number
ACI-05653
Product name
6-Methyl-benzo[d]isoxazol-3-ol
Purity
95%+
Packaging
1g
Price
$282.75
Updated
2021/12/16
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6-Methyl-1,2-benzisoxazol-3(2H)-one Chemical Properties,Usage,Production

Synthesis

158671-29-5

66571-26-4

GENERAL METHOD: N,2-Dihydroxy-4-methylbenzamide (77 mg, 0.5 mmol, 1 eq.) was dissolved in anhydrous THF (7 mL) under inert (N2) atmosphere. Triphenylphosphine (164 mg, 0.625 mmol, 1.25 eq.) was subsequently added. 2 min later, DIAD (123 μL, 0.625 mmol, 1.25 eq.) was slowly added dropwise. After 30 min of reaction, the completion of the reaction was confirmed by TLC (hexane/ethyl acetate, 1:3) monitoring. Upon completion of the reaction, THF was removed under reduced pressure.The residue was partitioned between 0.1 M NaOH solution (50 mL) and dichloromethane (100 mL). After separating the organic phase, the aqueous phase was washed three times with dichloromethane (100 mL). The organic phases were combined and the aqueous phase was acidified with 1 M HCl (10 mL) before extraction with dichloromethane (2 x 100 mL). All organic phases were combined, washed with saturated saline (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated to give 6-methyl-1,2-benzisoxazol-3(2H)-one.

References

[1] Tetrahedron Letters, 2016, vol. 57, # 48, p. 5301 - 5303
[2] Patent: US2005/143434, 2005, A1. Location in patent: Page/Page column 9
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 24, p. 8541 - 8554
[4] Patent: EP1988085, 2008, A1. Location in patent: Page/Page column 29-30
[5] Journal of Medicinal Chemistry, 2008, vol. 51, # 12, p. 3357 - 3359

6-Methyl-1,2-benzisoxazol-3(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Methyl-1,2-benzisoxazol-3(2H)-one Suppliers

China 39 India 4 United States 4 Global 47
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66571-26-4, 6-Methyl-1,2-benzisoxazol-3(2H)-oneRelated Search:


  • 6-Methyl-1,2-benzisoxazol-3(2H)-one
  • 6-Methylbenzo[d]isoxazol-3(2H)-one
  • 6-Methyl-1,2-benzoxazol-3-one
  • 6-Methylbenzo[d]isoxazol-3(2H)
  • 6-Methyl-1,2-benzisoxazol-3-ol
  • 1,2-Benzisoxazol-3(2H)-one, 6-methyl-
  • 66571-26-4