ChemicalBook > CAS DataBase List > 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine

2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine

Product Name: 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine
CAS No.: 1333222-12-0
Chemical Name: 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine
Synonyms: 6-(Difluoromethoxy)pyridin-3-ylboronic acid pinacol ester;2-(difluoromethoxy)-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine;Pyridine, 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2-(Difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine - [D27707]
CBNumber: CB52516540
Molecular Formula: C12H16BF2NO3
Formula Weight: 271.07
MOL File: 1333222-12-0.mol

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2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Colorless to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D126070
Product name: 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Synthonix

Product number: D27707
Product name: 2-(Difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity: 97%
Packaging: 100mg
Price: $170
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0006374
Product name: 2-(DIFLUOROMETHOXY)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $504.66
Updated: 2021/12/16

Synthonix

Product number: D27707
Product name: 2-(Difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity: 97%
Packaging: 1g
Price: $670
Updated: 2021/12/16

AK Scientific

Product number: 9880BB
Product name: 2-(Difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Packaging: 250mg
Price: $816
Updated: 2021/12/16

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2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine Chemical Properties,Usage,Production

Synthesis

1054483-78-1

1895-39-2

1333222-12-0

2-Hydroxypyridine-5-boronic acid pinacol ester (300 mg, 1.357 mmol), sodium difluorochloroacetate (320 mg, 2.036 mmol), and acetonitrile (5 mL) were sequentially added to a sealed reaction tube to form a suspension. The reaction mixture was heated to 80 °C and continuously stirred overnight. After completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate and washed sequentially with saturated aqueous sodium bicarbonate and brine. The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated. The target compound 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (197 mg, 53% yield) was purified by rapid chromatography on silica gel column (eluent: dichloromethane/methanol, 95/5). Mass spectrometry result: m/z 272.8 [M + H]+, retention time (Method 6): 3.12 min.

References

[1] Patent: WO2013/57711, 2013, A1. Location in patent: Page/Page column 49
[2] Patent: US2015/342951, 2015, A1. Location in patent: Paragraph 0859-0860

2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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1333222-12-0, 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridineRelated Search:

2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine

6-(Difluoromethoxy)pyridin-3-ylboronic acid pinacol ester

2-(difluoromethoxy)-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Pyridine, 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

2-(Difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine - [D27707]

1333222-12-0

C12H16BF2NO3