8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one

Product Name: 8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one
CAS No.: 98232-51-0
Chemical Name: 8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one
Synonyms: 8-methoxy-3,4-dihydro-2H-benzo[b]oxepin-5-one;8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one;1-Benzoxepin-5(2H)-one, 3,4-dihydro-8-methoxy-
CBNumber: CB52518261
Molecular Formula: C11H12O3
Formula Weight: 192.21
MOL File: 98232-51-0.mol

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8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one Property

Boiling point:: 140 °C(Press: 0.6 Torr)
Density: 1.161±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
Appearance: Yellow to brown Liquid

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Safety

HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M342553
Product name: 8-methoxy-2,3,4,5-tetrahydro-1-benzoxepin-5-one
Packaging: 25mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR956601
Product name: 8-Methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one
Purity: 95%
Packaging: 250mg
Price: $150
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H17-1-0T
Product name: 8-Methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one
Purity: 95%
Packaging: 250mg
Price: $240
Updated: 2021/12/16

Apolloscientific

Product number: OR956601
Product name: 8-Methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one
Purity: 95%
Packaging: 1g
Price: $370
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0391725
Product name: 8-METHOXY-3,4-DIHYDROBENZO[B]OXEPIN-5(2H)-ONE
Purity: 95.00%
Packaging: 5MG
Price: $495.39
Updated: 2021/12/16

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8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one Chemical Properties,Usage,Production

Synthesis

41214-27-1

98232-51-0

General procedure for the synthesis of 8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one from 3-methoxyphenoxybutyric acid: a chlorobenzene solution of polyphosphoric acid (PPA) was slowly added to compound Int-19d (22 g, 0.1 mol) at 80 °C and the reaction mixture was kept stirred continuously at 80 °C for about 15 hours. After completion of the reaction, the solvent was removed and the residue was dissolved in ethyl acetate and washed sequentially with 1N aqueous sodium hydroxide and saturated saline. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target compound Int-19e (14 g, 73% yield). The product was characterized by 1H NMR (CDCl3) with chemical shifts δ: 7.74 (d, J = 8Hz, 1H), 6.63 (d, J = 8Hz, 1H), 6.53 (s, 1H), 4.21 (t, J = 12Hz, 2H), 3.80 (s, 3H), 2.84 (t, J = 16Hz, 2H), 2.18-2.15 (m, 2H ).

References

[1] Patent: WO2012/50848, 2012, A1. Location in patent: Page/Page column 109-110
[2] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 23, p. 5025 - 5033
[3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 21, p. 9554 - 9573
[4] Justus Liebigs Annalen der Chemie, 1954, vol. 587, p. 38,47
[5] Synthetic Communications, 2009, vol. 39, # 15, p. 2664 - 2673

8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one Suppliers

China 13 India 1 United States 1 Global 15

Shanghai potentpharm CO.,Ltd

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Amadis Chemical Company Limited

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Biokitchen

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Aikon International Limited

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Career Henan Chemica Co

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Bide Pharmatech Ltd.

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Hebei Boxin Biotechnology Co. , Ltd.

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98232-51-0, 8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-oneRelated Search:

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98232-51-0