4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride

Product Name: 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride
CAS No.: 136647-02-4
Chemical Name: 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride
Synonyms: UK-78282 HCl;UK 78282 hydrochloride;UK-78282 monohydrochloride;UK-78282 monohydrochloride >=98% (HPLC);4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-pi;4-(Benzhydryloxymethyl)-1-[3-(4-methoxyphenyl)propyl]piperidine;4-(3,3-diphenylpropyl)-1-(3-(4-Methoxyphenyl)propyl)piperidine h;4-(3,3-diphenylpropyl)-1-(3-(4-methoxyphenyl)propyl)piperidine hydrochloride;4-((Benzhydryloxy)Methyl)-1-(3-(4-Methoxyphenyl)propyl)piperidine hydrochloride;4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride
CBNumber: CB52518807
Molecular Formula: C29H35NO2.HCl
Formula Weight: 466
MOL File: 136647-02-4.mol

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4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride Property

storage temp.: Store at -20°C
solubility: DMSO: >10mg/mL
form: solid
color: white to off-white

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Safety

Hazard Codes: Xi,N
Risk Statements: 36-50/53
Safety Statements: 26-60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: U3885
Product name: UK-78282 monohydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $180
Updated: 2024/03/01

Tocris

Product number: 3829
Product name: UK78282hydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $221
Updated: 2021/12/16

Tocris

Product number: 3829
Product name: UK78282hydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $924
Updated: 2021/12/16

TRC

Product number: U700625
Product name: UK78282Hydrochloride
Packaging: 25mg
Price: $450
Updated: 2021/12/16

Usbiological

Product number: 257021
Product name: UK 78282 hydrochloride
Packaging: 10mg
Price: $502
Updated: 2021/12/16

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4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride Chemical Properties,Usage,Production

Uses

UK 78282 Hydrochloride is used in the synthetic preparation of N-arylalkylpiperidine and -pyrrolidine derivatives for treating irritable bowel syndrome.

Biological Activity

UK-78282 blocks both Kv1.3 and Kv1.4. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. Selective blockers of Kv1.4 are desired, as there are few if any currently available. UK-78282 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. UK-78282 is also valuable for the study of Kv1.4 function.

storage

Store at -20°C

4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride Suppliers

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136647-02-4, 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochlorideRelated Search:

4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidinehydrochloride

UK 78282 hydrochloride

4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-pi

4-(3,3-diphenylpropyl)-1-(3-(4-Methoxyphenyl)propyl)piperidine h

4-((Benzhydryloxy)Methyl)-1-(3-(4-Methoxyphenyl)propyl)piperidine hydrochloride

4-(Benzhydryloxymethyl)-1-[3-(4-methoxyphenyl)propyl]piperidine

4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine monohydrochloride

UK-78282 monohydrochloride

4-(3,3-diphenylpropyl)-1-(3-(4-methoxyphenyl)propyl)piperidine hydrochloride

UK-78282 monohydrochloride >=98% (HPLC)

UK-78282 HCl

136647-02-4

C29H35NO2HCl

C29H36ClNO2