4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid
- Product Name
- 4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid
- CAS No.
- 6501-72-0
- Chemical Name
- 4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid
- Synonyms
- GIT 27;CS-1488;VGX-127;VGX-1027;VGX-1027, >=98%;VGX-1027(GIT 27);VGX-1027, 6501-72-0;VGX-1027, 10 mM in DMSO;VGX-1027 (Git-27), TLR4 inhibitior;3-Phenyl-2-isoxazoline-5-acetic acid
- CBNumber
- CB52518933
- Molecular Formula
- C11H11NO3
- Formula Weight
- 205.21
- MOL File
- 6501-72-0.mol
4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid Property
- Melting point:
- 157-158℃
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Soluble in DMSO (up to 30 mg/ml).
- form
- solid
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P285In case of inadequate ventilation wear respiratory protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P330Rinse mouth.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- V0160
- Product name
- VGX-1027
- Packaging
- 10MG
- Price
- $123
- Updated
- 2024/03/01
- Product number
- V0160
- Product name
- VGX-1027
- Packaging
- 50MG
- Price
- $370
- Updated
- 2024/03/01
- Product number
- 16293
- Product name
- GIT 27
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 16293
- Product name
- GIT 27
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 16293
- Product name
- GIT 27
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $239
- Updated
- 2024/03/01
4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid Chemical Properties,Usage,Production
Description
VGX-1027 (6501-72-0) is an immunomodulator that inhibits secretion of IL-1β, TNF-α, and IL-10 from murine macrophages stimulated with LPS and spares T cell function.1?Ameliorates the course of acute and chronic immunoinflammatory conditions such as carrageenan-induced pleurisy, LPS-induced lethality, and type II collagen-induced arthritis in mouse models.1?Prevents spontaneous and accelerated forms of autoimmune diabetes in a NOD mouse model.2?Modulates genes involved in LPS-induced Toll-like receptor 4 activation in a mouse Lupus model.3?Displays protective effects in particulate matter-induced acute lung injury by blocking TLR4 signaling.4
Uses
2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid reduces the secretion of IL-1β, TNF-α and IL-10 from purified murine macrophages but not of T cells; and reduces the activation of NF-κB and p38 MAP kinase pathways along with up-regulation of ERK pathways. 2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid inhibits proliferation of enterobacterial antigen-reactive CD4+CD25- T cells in vitro .
storage
Store at +4°C
References
1) Stojanovic?et al.?(2007),?In vitro, ex vivo and in vivo immunopharmacological activities of the isooxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models; Clin. Immunol.,?123?311 2) Stosic-Grujisic?et al.?(2007),?A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice; J. Pharmacol. Exp. Ther.,?320?1038 3) Fagone?et al.?(2014),?VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus; Immunology,?142?594 4) Xu?et al.?(2019),?Protective effects of VGX-1027 in PM2.5-induced airway inflammation and bronchial hyperresponsiveness; Eur. J, Pharmacol.,?842?373
4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid Preparation Products And Raw materials
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