7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine

Product Name: 7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine
CAS No.: 768350-54-5
Chemical Name: 7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine
Synonyms: 7-(Benzyloxy)-4-(4-bromo-2-fluoroanilino)-6-methoxyquinazoline;7-Benzyloxy-6-Methoxy-4-(4''-broMo-2''-fluoroanilino)-quinazoline;7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine;N-(4-bromo-2-fluorophenyl)-6-methoxy-7-phenylmethoxyquinazolin-4-amine;4-QuinazolinaMine, N-(4-broMo-2-fluorophenyl)-6-Methoxy-7-(phenylMethoxy)-;7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine ISO 9001：2015 REACH
CBNumber: CB52520763
Molecular Formula: C22H17BrFN3O2
Formula Weight: 454.29
MOL File: 768350-54-5.mol

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7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine Property

Melting point:: 244-246 °C
Boiling point:: 541.1±50.0 °C(Predicted)
Density: 1.488
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 5.44±0.30(Predicted)
InChI: InChI=1S/C22H17BrFN3O2/c1-28-20-10-16-19(11-21(20)29-12-14-5-3-2-4-6-14)25-13-26-22(16)27-18-8-7-15(23)9-17(18)24/h2-11,13H,12H2,1H3,(H,25,26,27)
InChIKey: UPEHYJHYPMGWJC-UHFFFAOYSA-N
SMILES: N1=C2C(C=C(OC)C(OCC3=CC=CC=C3)=C2)=C(NC2=CC=C(Br)C=C2F)N=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0368195
Product name: 7-(BENZYLOXY)-N-(4-BROMO-2-FLUOROPHENYL)-6-METHOXYQUINAZOLIN-4-AMINE
Purity: 95.00%
Packaging: 5MG
Price: $497.09
Updated: 2021/12/16

Matrix Scientific

Product number: 100548
Product name: 7-(Benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine
Purity: 95+%
Packaging: 250mg
Price: $742
Updated: 2021/12/16

Matrix Scientific

Product number: 100548
Product name: 7-(Benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine
Purity: 95+%
Packaging: 1g
Price: $1647
Updated: 2021/12/16

Crysdot

Product number: CD11059905
Product name: 7-(Benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine
Purity: 95+%
Packaging: 1g
Price: $772
Updated: 2021/12/16

Alichem

Product number: 768350545
Product name: 7-(Benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine
Packaging: 1g
Price: $795.6
Updated: 2021/12/16

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7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine Chemical Properties,Usage,Production

Synthesis

367-24-8

162364-72-9

768350-54-5

General procedure for the synthesis of 7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine from 4-bromo-2-fluoroaniline and 7-benzyloxy-4-chloro-6-methoxyquinazoline: 6.5 M hydrogen chloride (2.54 mL) was added to a 2-propanol (160 mL) solution containing 4-bromo-2-fluoroaniline (4.51 g, 15.0 mmol) and 7-benzyloxy-4- chloro-6-methoxyquinazoline (2.40 g, 16.5 mmol) in a solution of 2-propanol (160 mL). Subsequently, the reaction mixture was heated to reflux and kept for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the precipitated solid product was collected by filtration. The solid was washed sequentially with 2-propanol and ether and finally dried under vacuum overnight to afford the target compound 7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine (7.9 g, 94% yield) as a white solid.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 11, p. 3222 - 3226
[2] Patent: WO2005/13998, 2005, A1. Location in patent: Page/Page column 75
[3] Patent: US2010/75916, 2010, A1. Location in patent: Page/Page column 16
[4] Patent: WO2005/97134, 2005, A2. Location in patent: Page/Page column 16-17; figure 2
[5] Patent: US2009/238808, 2009, A1

7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine 768350-54-5
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-17

Nanjing Fred Technology Co., Ltd

Product: 7-(Benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine 768350-54-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-28

Yangzhou Qinyuan Pharmatech Co.,ltd

Product: 7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine 768350-54-5
Price: US $10.00/g
Min. Order: 10g
Purity: 0.99
Supply Ability: 1ton
Release date: 2024-10-31

768350-54-5, 7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amineRelated Search:

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7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine

7-(Benzyloxy)-4-(4-bromo-2-fluoroanilino)-6-methoxyquinazoline

7-Benzyloxy-6-Methoxy-4-(4''-broMo-2''-fluoroanilino)-quinazoline

4-QuinazolinaMine, N-(4-broMo-2-fluorophenyl)-6-Methoxy-7-(phenylMethoxy)-

7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine ISO 9001：2015 REACH

N-(4-bromo-2-fluorophenyl)-6-methoxy-7-phenylmethoxyquinazolin-4-amine

768350-54-5