3-Ethynyl-1-azetidinecarboxylic acid tert-butyl ester
- Product Name
- 3-Ethynyl-1-azetidinecarboxylic acid tert-butyl ester
- CAS No.
- 287193-01-5
- Chemical Name
- 3-Ethynyl-1-azetidinecarboxylic acid tert-butyl ester
- Synonyms
- 1-Boc-3-ethynylazetidine;1-Boc-3-methylazetidine,95%;tert-butyl 3-ethynylazetidine-1-carboxylate;3-Ethynyl-1-azetidinecarboxylic acid tert-butyl ester;tert-Butyl 3-ethynylazetidine-1-carboxylate - [B0567];3-Ethynyl-azetidine-1-carboxylic acid tert-butyl ester;1-Azetidinecarboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester
- CBNumber
- CB52521098
- Molecular Formula
- C10H15NO2
- Formula Weight
- 181.23
- MOL File
- 287193-01-5.mol
3-Ethynyl-1-azetidinecarboxylic acid tert-butyl ester Property
- Boiling point:
- 228℃
- Density
- 1.05
- Flash point:
- 92℃
- storage temp.
- 2-8°C
- pka
- -2.81±0.40(Predicted)
- Appearance
- Colorless to off-white Liquid
- InChI
- InChI=1S/C10H15NO2/c1-5-8-6-11(7-8)9(12)13-10(2,3)4/h1,8H,6-7H2,2-4H3
- InChIKey
- UENGYBYGCXKNRF-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CC(C#C)C1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B871015
- Product name
- tert-Butyl3-ethynylazetidine-1-carboxylate
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- B691
- Product name
- 1-Boc-3-ethynylazetidine
- Packaging
- 500mg
- Price
- $304
- Updated
- 2021/12/16
- Product number
- AS12478
- Product name
- 1-Boc-3-(ethynyl)azetidine
- Purity
- 96%
- Packaging
- 1g
- Price
- $348
- Updated
- 2021/12/16
- Product number
- 068803
- Product name
- tert-Butyl 3-ethynylazetidine-1-carboxylate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $429
- Updated
- 2021/12/16
- Product number
- CHM0394051
- Product name
- TERT-BUTYL-3-ETHYNYLAZETIDINE-1-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.86
- Updated
- 2021/12/16
3-Ethynyl-1-azetidinecarboxylic acid tert-butyl ester Chemical Properties,Usage,Production
Synthesis
177947-96-5
90965-06-3
287193-01-5
To a stirred solution of tert-butyl 3-formylazetidine-1-carboxylate (1.3 g, 27 mmol) in methanol (70 ml) was added dimethyl (1-diazido-2-oxopropyl)phosphonate (6 g, 31.2 mmol) followed by potassium carbonate (14.92 g, 108 mmol) at 0 °C. The reaction mixture was stirred at 0 °C for 3 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (150 ml), filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by fast chromatography (silica gel, eluent: 0-100% hexane solution of ethyl acetate) to give tert-butyl 3-alkynyl-1-azetidinecarboxylate (4.6 g, 94%).1H NMR (400 MHz, DMSO-d6) δ 1.34 (s, 9H), 3.22-3.23 (m, 1H), 3.34-3.39 (m, 1H ), 3.68 (t, J = 6.8 Hz, 2H), 4.04 (t, J = 8.4 Hz, 2H).
References
[1] Patent: WO2014/165075, 2014, A1. Location in patent: Page/Page column 46; 47
[2] Patent: WO2016/4413, 2016, A2. Location in patent: Paragraph 0279
[3] Patent: US2018/86709, 2018, A1. Location in patent: Paragraph 0358-0359
[4] Patent: WO2015/51244, 2015, A1. Location in patent: Paragraph 00655; 00709
[5] Patent: WO2016/105485, 2016, A2. Location in patent: Paragraph 0219
3-Ethynyl-1-azetidinecarboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Ethynyl-1-azetidinecarboxylic acid tert-butyl ester manufacturers
- Product
- 3-Ethynyl-1-azetidinecarboxylic acid tert-butyl ester 287193-01-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2019-12-31