methyl 2-chlorothiazole-5-carboxylate
- Product Name
- methyl 2-chlorothiazole-5-carboxylate
- CAS No.
- 72605-86-8
- Chemical Name
- methyl 2-chlorothiazole-5-carboxylate
- Synonyms
- 5-Carbomethoxy-2-chlorothiazole;Methyl 2-chloro-thiazol-5-carboxylate;Methyl 2-chloro-5-thiazolecarboxylate;2-Chloro-5-(methoxycarbonyl)-1,3-thiazole;Methyl 2-chlorothiazole-5-carboxylate 97%;2-Chlorothiazole-5-carboxylic acid methyl ester;2-Chloro-5-thiazolecarboxylic acid methyl ester;2-Chloro-thiazole-5-Carbocylic acid methyl ester;5-Thiazolecarboxylic acid, 2-chloro-, Methyl ester;2-chloro-5-Thiazolecarboxylic acid methyl ester (9CI ACI)
- CBNumber
- CB52521391
- Molecular Formula
- C5H4ClNO2S
- Formula Weight
- 177.61
- MOL File
- 72605-86-8.mol
methyl 2-chlorothiazole-5-carboxylate Property
- Boiling point:
- 271.2±32.0 °C(Predicted)
- Density
- 1.456±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -1.09±0.10(Predicted)
- form
- powder
- color
- White
Safety
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SYX00302
- Product name
- Methyl 2-chlorothiazole-5-carboxylate
- Packaging
- 1g
- Price
- $107
- Updated
- 2025/07/31
- Product number
- M340403
- Product name
- Methyl 2-chlorothiazole-5-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- W8118
- Product name
- Methyl 2-chlorothiazole-5-carboxylate
- Packaging
- 1g
- Price
- $84
- Updated
- 2021/12/16
- Product number
- 069592
- Product name
- Methyl 2-chlorothiazole-5-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-0038286
- Product name
- Methyl 2-chlorothiazole-5-carboxylate
- Packaging
- 5g
- Price
- $107
- Updated
- 2021/12/16
methyl 2-chlorothiazole-5-carboxylate Chemical Properties,Usage,Production
Synthesis
726185-57-5
72605-86-8
A suspension was prepared from methyl 2-aminothiazole-5-carboxylate hydrochloride (14.0 g, 71.927 mmol) in 8 ml of concentrated hydrochloric acid to which 20 g of crushed ice was added. An aqueous solution (30 ml) of sodium nitrite (5.0 g, 72.464 mmol) was added slowly and dropwise under external cooling conditions, ensuring that the reaction temperature was maintained below 0 °C at all times. After 30 min of reaction, copper(I) chloride (7.2 g, 72.735 mmol) was added and stirring was continued under cooling conditions for 1 h, followed by a slow warming up to room temperature over 1.5 h. The reaction was completed with the addition of ether. After completion of the reaction, the reaction mixture was thoroughly extracted with ether, the organic phases were combined, washed with saturated brine solution, dried over anhydrous sodium sulfate and the solvent was subsequently evaporated. Methyl 2-chlorothiazole-5-carboxylate 4.3 g (34% yield) was obtained as a colorless oil with a thin layer chromatographic Rf value of 0.94 (Unfolding agent: EI D). The product was used directly in the next reaction without further purification. Mass spectrometry analysis showed the molecular ion peak M+ = 177/179 (Cl isotope peak).
References
[1] Patent: US2004/192729, 2004, A1. Location in patent: Page 34
methyl 2-chlorothiazole-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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