2-Bromo-3-fluoro-6-picoline
Uses- Product Name
- 2-Bromo-3-fluoro-6-picoline
- CAS No.
- 374633-36-0
- Chemical Name
- 2-Bromo-3-fluoro-6-picoline
- Synonyms
- 2-bromo-3-fluoro-6-methylpyridine;2-Bromo-3-fL;uoro-6-methyL;6-Bromo-5-fluoro-2-picoline;2-BROMO-3-FLUORO-6-PICOLINE;Pyridine, 2-bromo-3-fluoro-6-methyl-;2-Bromo-3-fluoro-6-methylpyridine,98%;2-BROMO-3-FLUORO-6-PICOLINE ISO 9001：2015 REACH
- CBNumber
- CB5252466
- Molecular Formula
- C6H5BrFN
- Formula Weight
- 190.01
- MOL File
- 374633-36-0.mol
2-Bromo-3-fluoro-6-picoline Property
- Boiling point:
- 185.6±35.0 °C(Predicted)
- Density
- 1.592±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -0.91±0.10(Predicted)
- form
- Solid
- Appearance
- White to light yellow Solid
- InChI
- InChI=1S/C6H5BrFN/c1-4-2-3-5(8)6(7)9-4/h2-3H,1H3
- InChIKey
- KKVUMKHUMBXLMH-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC(C)=CC=C1F
- CAS DataBase Reference
- 374633-36-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- AGN00010
- Product name
- 2-Bromo-3-fluoro-6-methylpyridine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $330
- Updated
- 2025/07/31
- Product number
- B685188
- Product name
- 2-Bromo-3-fluoro-6-picoline
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- B685188
- Product name
- 2-Bromo-3-fluoro-6-picoline
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 415761
- Product name
- 2-Bromo-3-fluoro-6-picoline
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- PC49163
- Product name
- 2-Bromo-3-fluoro-6-methylpyridine
- Packaging
- 1g
- Price
- $13
- Updated
- 2021/12/16
2-Bromo-3-fluoro-6-picoline Chemical Properties,Usage,Production
Uses
2-Bromo-3-fluoro-6-methylpyridine is used as an intermediate in organic synthesis and pesticides.
Synthesis
3-Amino-2-bromo-6-methylpyridine or 4-amino-2-bromo-6-methylpyridine (25.20 g, 134.73 mmol) was added to a mixture of water (78.1 mL) and conc. HCl (12.8 mL, 350.30 mmol), and then the mixture was cooled to 0 ℃. To it, sodium nitrite (18.6 g,269.46 mmol) was added portion-wise with stirring over 20 min while keeping the reaction temperature between –5 ℃and 0 ℃. After 10 min, 65 per cent hexafluorophosphoric acid solution (43.26 g, 296.41 mmol) was added dropwise with cooling, at which point many precipitates were formed. The precipitates were collected by filtration using a glass filter funnel, washed with cold water (2 × 50 mL) and diethyl ether (100 mL), and then dried in the air for 48 h. The solid was slowly heated to 100 ℃ (very exothermic), and a dark, oily material was formed after 10 min. The oil was basified with diluted NaOH solution to pH~10 and extracted with CH2Cl2 (2 × 150 mL). The combined organic layer was dried over anhydrous Na2SO4, filtered, and evaporated to dryness under reduced pressure. The residue was purified by MPLC on neutral alumina using hexane/EtOAc (10:1) as an eluent to afford 2-Bromo-3-fluoro-6-picoline.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 22, p. 5228 - 5231
2-Bromo-3-fluoro-6-picoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-3-fluoro-6-picoline manufacturers
- Product
- 2-BROMO-3-FLUORO-6-PICOLINE 374633-36-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-25
- Product
- 2-BROMO-3-FLUORO-6-PICOLINE 374633-36-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 2-BROMO-3-FLUORO-6-PICOLINE 374633-36-0
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-10