2-Oxa-6-azaspiro[3.3]heptane, 6-[(4-methylphenyl)sulfonyl]-
- Product Name
- 2-Oxa-6-azaspiro[3.3]heptane, 6-[(4-methylphenyl)sulfonyl]-
- CAS No.
- 13573-28-9
- Chemical Name
- 2-Oxa-6-azaspiro[3.3]heptane, 6-[(4-methylphenyl)sulfonyl]-
- Synonyms
- 6-[(4-Methylphenyl)sulfonyl]-2-oxa-6-azaspiro[3.3]heptane;104139;6-(p-toluenesulfonyl)-2-o...;6-(p-toluenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane;6-(4-methylbenzenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane;2-Oxa-6-azaspiro[3.3]heptane, 6-[(4-Methylphenyl)sulfonyl]-;6-(p-Toluenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane - [T6175]
- CBNumber
- CB52525197
- Molecular Formula
- C12H15NO3S
- Formula Weight
- 253.32
- MOL File
- 13573-28-9.mol
2-Oxa-6-azaspiro[3.3]heptane, 6-[(4-methylphenyl)sulfonyl]- Property
- Boiling point:
- 411.0±55.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -6.15±0.20(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C12H15NO3S/c1-10-2-4-11(5-3-10)17(14,15)13-6-12(7-13)8-16-9-12/h2-5H,6-9H2,1H3
- InChIKey
- DVSLPPSXVDZQHH-UHFFFAOYSA-N
- SMILES
- C1C2(CN(S(C3=CC=C(C)C=C3)(=O)=O)C2)CO1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T733828
- Product name
- 6-Tosyl-2-oxa-6-azaspiro[3.3]heptane
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 8H69-1-2Z
- Product name
- 6-(p-Toluenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- T6175
- Product name
- 6-(p-Toluenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane
- Purity
- 97.0%
- Packaging
- 5g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 8H69-1-2Z
- Product name
- 6-(p-Toluenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane
- Packaging
- 5G
- Price
- $270
- Updated
- 2021/12/16
- Product number
- 070680
- Product name
- 6-(p-Toluenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane
- Purity
- 94%
- Packaging
- 1g
- Price
- $416
- Updated
- 2021/12/16
2-Oxa-6-azaspiro[3.3]heptane, 6-[(4-methylphenyl)sulfonyl]- Chemical Properties,Usage,Production
Synthesis
1522-92-5
70-55-3
13573-28-9
General procedure for the synthesis of 6-(p-toluenesulfonyl)-2-oxo-6-azaspiro[3.3]heptane by the reaction of 2,2-bis(bromomethyl)-3-bromo-1-propanol with p-toluenesulfonamide: 1. prepare a reaction solution by dissolving KOH (179 g, 3.2 mol) and p-toluenesulfonamide (205 g, 1.2 mol) in 1500 mL of ethanol. 2. 2,2-bis(bromomethyl)-3-bromo-1-propanol (324 g, 1.0 mol) was slowly added to the above solution at room temperature. 3. The reaction mixture was heated to reflux and kept reacting for 90 hours. 4. Upon completion of the reaction, the solvent was removed by evaporation. 5. 2000 mL of 1M KOH solution was added to the residue to form a white suspension, which continued to be stirred at room temperature for 2 hours. 6. The reaction mixture was filtered and the white filter cake was washed repeatedly with water until the wash water was neutral. 7. The filter cake was dried under high vacuum to afford the target product N-toluenesulfonyl-2-oxa-6-azaspiro[3.3]heptane (5,192 g, 76% yield) as a white solid. Product characterization data: 1H NMR (400 MHz, CDCl3): δ 7.69 (d, 2H, J = 8.4 Hz), 7.47 (d, 2H, J = 8.4 Hz), 4.42 (s, 4H), 3.85 (s, 4H), 2.41 (s, 3H). 13C NMR (100 MHz, CDCl3): δ 144.4, 130.9, 130.2, 128.5, 79.1, 59.5, 37.3, 21.3.
References
[1] Fitoterapia, 2014, vol. 92, p. 111 - 115
[2] Patent: US2012/252777, 2012, A1. Location in patent: Page/Page column 83
[3] Patent: WO2010/141817, 2010, A1. Location in patent: Page/Page column 29
[4] Patent: WO2011/143365, 2011, A1. Location in patent: Page/Page column 192
[5] Patent: WO2017/15106, 2017, A1. Location in patent: Page/Page column 40; 42; 138
2-Oxa-6-azaspiro[3.3]heptane, 6-[(4-methylphenyl)sulfonyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Oxa-6-azaspiro[3.3]heptane, 6-[(4-methylphenyl)sulfonyl]- manufacturers
- Product
- 6-(p-Toluenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane 13573-28-9
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-11-28
- Product
- 6-(p-Toluenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane 13573-28-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-08-15