[1-(tert-butoxycarbonyl)-4-methylpiperidin-4-yl]acetic acid

Product Name: [1-(tert-butoxycarbonyl)-4-methylpiperidin-4-yl]acetic acid
CAS No.: 872850-31-2
Chemical Name: [1-(tert-butoxycarbonyl)-4-methylpiperidin-4-yl]acetic acid
Synonyms: 1-Boc-4-methylpiperidine-4-acetic Acid;1-Boc-4-methyl-4-piperidineacetic acid;2-(1-tert-butoxycarbonyl-4-methyl-4-piperidyl)acetic acid;[1-(tert-butoxycarbonyl)-4-methylpiperidin-4-yl]acetic acid;2-(1-(tert-Butoxycarbonyl)-4-Methylpiperidin-4-yl)acetic acid;4-Piperidineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-4-methyl-
CBNumber: CB52525425
Molecular Formula: C13H23NO4
Formula Weight: 257.33
MOL File: 872850-31-2.mol

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[1-(tert-butoxycarbonyl)-4-methylpiperidin-4-yl]acetic acid Property

Boiling point:: 374.3±15.0 °C(Predicted)
Density: 1.093±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 4.66±0.10(Predicted)
Appearance: white solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB141065
Product name: 2-(1-(tert-Butoxycarbonyl)-4-methylpiperidin-4-yl)acetic acid
Packaging: 50mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141065
Product name: 2-(1-(tert-Butoxycarbonyl)-4-methylpiperidin-4-yl)acetic acid
Packaging: 100mg
Price: $113
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141065
Product name: 2-(1-(tert-Butoxycarbonyl)-4-methylpiperidin-4-yl)acetic acid
Packaging: 250mg
Price: $225
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141065
Product name: 2-(1-(tert-Butoxycarbonyl)-4-methylpiperidin-4-yl)acetic acid
Packaging: 500mg
Price: $390
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141065
Product name: 2-(1-(tert-Butoxycarbonyl)-4-methylpiperidin-4-yl)acetic acid
Packaging: 1g
Price: $681.25
Updated: 2021/12/16

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[1-(tert-butoxycarbonyl)-4-methylpiperidin-4-yl]acetic acid Chemical Properties,Usage,Production

Uses

2-(1-(tert-Butoxycarbonyl)-4-methylpiperidin-4-yl)acetic Acid can be useful in the preparation of piperazine derivatives as capsid protein inhibitors and also in the treatment of cancer.

Synthesis

872850-30-1

872850-31-2

Step 4: Preparation of [1-(tert-butoxycarbonyl)-4-methylpiperidin-4-yl]acetic acid: tert-butyl 4-(cyanomethyl)-4-methylpiperidine-1-carboxylate (4.5 g, 18.9 mmol) was dissolved in concentrated hydrochloric acid (100 mL) and the reaction was reacted at reflux for 48 hr. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with water (200 mL), and the pH was subsequently adjusted to 12 with 2 M NaOH solution. di-tert-butyl dicarbonate (4.12 g, 18.9 mmol) was added to the reaction system and the reaction was stirred for 16 h at room temperature. At the end of the reaction, the solvent was removed by evaporation and the pH was adjusted to 5 with 2 M HCl solution.The aqueous phase was extracted with dichloromethane (200 mL), the organic phases were combined, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford the brown oily product [1-(tert-butoxycarbonyl)-4-methylpiperidin-4-yl]acetic acid (3.54 g, 72% yield). NMR hydrogen spectral (CDCl3) data: δ 1.2 (s, 3H), 1.5-1.7 (m, 13H), 2.4 (s, 2H), 3.4 (m, 2H), 3.6 (m, 2H).

References

[1] Patent: WO2006/1752, 2006, A1. Location in patent: Page/Page column 72

[1-(tert-butoxycarbonyl)-4-methylpiperidin-4-yl]acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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[1-(tert-butoxycarbonyl)-4-methylpiperidin-4-yl]acetic acid Suppliers

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872850-31-2, [1-(tert-butoxycarbonyl)-4-methylpiperidin-4-yl]acetic acidRelated Search:

[1-(tert-butoxycarbonyl)-4-methylpiperidin-4-yl]acetic acid

2-(1-(tert-Butoxycarbonyl)-4-Methylpiperidin-4-yl)acetic acid

1-Boc-4-methyl-4-piperidineacetic acid

2-(1-tert-butoxycarbonyl-4-methyl-4-piperidyl)acetic acid

4-Piperidineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-4-methyl-

1-Boc-4-methylpiperidine-4-acetic Acid

872850-31-2