3-ethyl-4-fluorobenzonitrile
- Product Name
- 3-ethyl-4-fluorobenzonitrile
- CAS No.
- 869299-63-8
- Chemical Name
- 3-ethyl-4-fluorobenzonitrile
- Synonyms
- 3-ethyl-4-fluorobenzonitrile;Benzonitrile, 3-ethyl-4-fluoro-
- CBNumber
- CB52526068
- Molecular Formula
- C9H8FN
- Formula Weight
- 149.16
- MOL File
- 869299-63-8.mol
3-ethyl-4-fluorobenzonitrile Property
- Boiling point:
- 219.2±20.0 °C(Predicted)
- Density
- 1.08±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E939525
- Product name
- 3-Ethyl-4-fluorobenzonitrile
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- J52749
- Product name
- 3-Ethyl-4-fluorobenzonitrile
- Packaging
- 1g
- Price
- $104
- Updated
- 2021/12/16
- Product number
- CS-0069515
- Product name
- 3-Ethyl-4-fluorobenzonitrile
- Packaging
- 1g
- Price
- $104
- Updated
- 2021/12/16
- Product number
- CS-0069515
- Product name
- 3-Ethyl-4-fluorobenzonitrile
- Packaging
- 5g
- Price
- $313
- Updated
- 2021/12/16
- Product number
- CS-0069515
- Product name
- 3-Ethyl-4-fluorobenzonitrile
- Packaging
- 10g
- Price
- $470
- Updated
- 2021/12/16
3-ethyl-4-fluorobenzonitrile Chemical Properties,Usage,Production
Synthesis
557-20-0
79630-23-2
869299-63-8
3-Bromo-4-fluorobenzonitrile (200 g, 1 mol) and [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride dichloromethane complex (4.08 g, 5 mmol) were used as raw materials, which were dissolved in THF (1.2 L). A 1.0 M solution of diethylzinc hexane (600 mL, 0.6 mol) was slowly added at 40-50 °C, followed by heating the reaction mixture to 50-60 °C and maintaining the reaction for 4-5 hours. Complete reaction of the feedstock was confirmed by TLC monitoring. After completion of the reaction, the mixture was cooled to room temperature and quenched by addition of 5% dilute hydrochloric acid (1 L). The organic and aqueous layers were separated and the organic layer was washed twice with 500 mL of water followed by removal of solvent by concentration under reduced pressure. Hexane (600mL) and activated carbon (20g) were added to the concentrate and refluxed for 0.5 hours. After cooling to room temperature and filtration, activated carbon (10 g) was added to the filtrate and refluxing was repeated for 0.5 h. The filtrate was cooled and filtered. The filtrate was cooled to -50°C to -60°C and filtered to collect the solid. The resulting solid was dried under reduced pressure at 10-20 °C to give 3-ethyl-4-fluorobenzonitrile (112 g, 75% yield) as a white solid.
References
[1] Patent: CN108623496, 2018, A. Location in patent: Page/Page column 0049-0051; 0063-0065
3-ethyl-4-fluorobenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-ethyl-4-fluorobenzonitrile manufacturers
- Product
- 3-ethyl-4-fluorobenzonitrile 869299-63-8
- Price
- US $101.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-28
- Product
- 3-ethyl-4-fluorobenzonitrile 869299-63-8
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-11