1-(5-bromopyrimidin-2-yl)ethanone
- Product Name
- 1-(5-bromopyrimidin-2-yl)ethanone
- CAS No.
- 1189169-37-6
- Chemical Name
- 1-(5-bromopyrimidin-2-yl)ethanone
- Synonyms
- 2-Acetyl-5-bromopyrimidine;1-(5-Bromo-2-pyrimidinyl)ethane;1-(5-BroMo-2-pyriMidinyl)ethanone;1-(5-bromopyrimidin-2-yl)ethanone;1-(5-broMopyriMidin-2-yl)ethan-1-one;Ethanone, 1-(5-bromo-2-pyrimidinyl)-;1-(5-bromopyrimidin-2-yl-4,6-d2)ethan-1-one
- CBNumber
- CB52533954
- Molecular Formula
- C6H5BrN2O
- Formula Weight
- 201.02
- MOL File
- 1189169-37-6.mol
1-(5-bromopyrimidin-2-yl)ethanone Property
- Boiling point:
- 318.6±34.0 °C(Predicted)
- Density
- 1.626±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -2.43±0.22(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C6H5BrN2O/c1-4(10)6-8-2-5(7)3-9-6/h2-3H,1H3
- InChIKey
- NZGSEUQFYKCKRU-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=NC=C(Br)C=N1)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B129690
- Product name
- 1-(5-Bromopyrimidin-2-yl)ethanone
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 9479BB
- Product name
- 1-(5-Bromopyrimidin-2-yl)ethanone
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 114245
- Product name
- 1-(5-Bromopyrimidin-2-yl)ethanone
- Purity
- 97%
- Packaging
- 1g
- Price
- $134
- Updated
- 2021/12/16
- Product number
- 9479BB
- Product name
- 1-(5-Bromopyrimidin-2-yl)ethanone
- Packaging
- 1g
- Price
- $159
- Updated
- 2021/12/16
- Product number
- 4H56-9-3D
- Product name
- 1-(5-Bromopyrimidin-2-yl)ethan-1-one
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $190
- Updated
- 2021/12/16
1-(5-bromopyrimidin-2-yl)ethanone Chemical Properties,Usage,Production
Synthesis
75-16-1
38275-57-9
1189169-37-6
1. 5-bromo-2-cyanopyrimidine (221 mg, 1.2 mmol) was dissolved in anhydrous THF (10 mL) under nitrogen protection and cooled to -78 °C. The reaction temperature was reduced to -78 °C by a slow dropwise addition of THF solution of methylmagnesium bromide (3.0 mL, 4.20 mmol, 1.4 M). 2. slowly add THF solution of methylmagnesium bromide (3.0 mL, 4.20 mmol, 1.4 M) dropwise and maintain the reaction temperature at -78 °C. 3. the reaction mixture was stirred continuously at -78 °C for 3.5 hours. 4. Upon completion of the reaction, the reaction was quenched with saturated aqueous NH4Cl solution. 5. The reaction mixture was extracted with EtOAc and the organic layers were combined. 6. The organic layer was dried with anhydrous Na2SO4, filtered and concentrated. 7. 7. Purify the crude product by silica gel column chromatography with an eluent ratio of petroleum ether:EtOAc (1:0 to 0:1). 8. The target fraction was collected and concentrated to give 1-(5-bromopyrimidin-2-yl)ethanone (1.55 mg, 61% yield). 9. The product was analyzed by 1H NMR. 9. The product was characterized by 1H NMR (CDCl3, 500 MHz): δ 9.00 (s, 2H), 2.80 (s, 3H).
References
[1] Patent: US2014/107335, 2014, A1. Location in patent: Paragraph 0172; 0173
[2] Patent: WO2018/97945, 2018, A1. Location in patent: Paragraph 0528
[3] Patent: US2009/253708, 2009, A1. Location in patent: Page/Page column 15
1-(5-bromopyrimidin-2-yl)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(5-bromopyrimidin-2-yl)ethanone manufacturers
- Product
- 1-(5-bromopyrimidin-2-yl)ethanone 1189169-37-6
- Price
- US $60.00/KG
- Min. Order
- 1KG
- Purity
- 99.9%
- Supply Ability
- 10tons
- Release date
- 2020-09-01
- Product
- 1-(5-bromopyrimidin-2-yl)ethanone 1189169-37-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-13