3-Bromo-6-fluoropicolinic acid
- Product Name
- 3-Bromo-6-fluoropicolinic acid
- CAS No.
- 1211589-43-3
- Chemical Name
- 3-Bromo-6-fluoropicolinic acid
- Synonyms
- 3-Bromo-6-fluoropicolinic acid;3-Bromo-6-fluoropyridine-2-carboxylicacid;2-Pyridinecarboxylic acid, 3-bromo-6-fluoro-;3-bromo-6-fluoro-pyridine-2-carboxylic acid - [B81710]
- CBNumber
- CB52534926
- Molecular Formula
- C6H3BrFNO2
- Formula Weight
- 220
- MOL File
- 1211589-43-3.mol
3-Bromo-6-fluoropicolinic acid Property
- Boiling point:
- 321.3±42.0 °C(Predicted)
- Density
- 1.903±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.95±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B961540
- Product name
- 3-Bromo-6-fluoropicolinicAcid
- Packaging
- 100mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 4H21-B-00
- Product name
- 3-Bromo-6-fluoropyridine-2-carboxylic acid
- Packaging
- 250mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- PC49090
- Product name
- 3-Bromo-6-fluoropyridine-2-carboxylicacid
- Packaging
- 250mg
- Price
- $295
- Updated
- 2021/12/16
- Product number
- 116267
- Product name
- 3-Bromo-6-fluoropicolinic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $384
- Updated
- 2021/12/16
- Product number
- 4H21-B-00
- Product name
- 3-Bromo-6-fluoropyridine-2-carboxylic acid
- Packaging
- 1g
- Price
- $495
- Updated
- 2021/12/16
3-Bromo-6-fluoropicolinic acid Chemical Properties,Usage,Production
Synthesis
375368-83-5
1211589-43-3
General procedure for the synthesis of 3-bromo-6-fluoropyridine-2-carboxylic acid from 3-bromo-2-methyl-6-fluoropyridine: 3-bromo-2-methyl-6-fluoropyridine (5 kg) was dissolved in concentrated sulfuric acid (50 kg). After warming the reaction system to 60 °C, chromium trioxide (CrO3, 16 kg) was added in batches. After the addition was completed, the reaction was continued at 60 °C with stirring for 18 h, during which the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction solution was adjusted to neutral with 20% sodium hydroxide (NaOH) solution. Subsequently, ethyl acetate (50 L × 3) was added to the reaction solution for extraction. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The resulting crude product was purified by slurrying with hexane, filtered and dried to give 3-bromo-6-fluoropyridine-2-carboxylic acid as a white solid (3.8 kg, 58% yield).
References
[1] Patent: CN108341769, 2018, A. Location in patent: Paragraph 0021; 0022; 0024; 0025; 0026; 0028
[2] Patent: CN108503581, 2018, A. Location in patent: Paragraph 0031-0032; 0039; 0041; 0043
3-Bromo-6-fluoropicolinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Bromo-6-fluoropicolinic acid manufacturers
- Product
- 3-Bromo-6-fluoropicolinic acid 1211589-43-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200g
- Release date
- 2020-02-01