TC-H 106
- Product Name
- TC-H 106
- CAS No.
- 937039-45-7
- Chemical Name
- TC-H 106
- Synonyms
- RGFA 8;TC-H 106;Compound 106;Inhibitor 106;TC-H 106, >98%;Pimelic Diphenylamide 106;Pimelic Diphenylamide 106, >98%;Histone Deacetylase Inhibitor VII;Pimelic Diphenylamide 106(TC-H 106);Histone Deacetylase Inhibitor VII, 106
- CBNumber
- CB52538287
- Molecular Formula
- C20H25N3O2
- Formula Weight
- 339.43
- MOL File
- 937039-45-7.mol
TC-H 106 Property
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥15mg/mL
- form
- Yellow solid
- color
- white to beige
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML0313
- Product name
- Pimelic Diphenylamide 106
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $113
- Updated
- 2024/03/01
- Product number
- 382173
- Product name
- Histone Deacetylase Inhibitor VII, 106
- Packaging
- 5mg
- Price
- $532
- Updated
- 2024/03/01
- Product number
- 13212
- Product name
- Pimelic Diphenylamide 106
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $26
- Updated
- 2024/03/01
- Product number
- 13212
- Product name
- Pimelic Diphenylamide 106
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- SML0313
- Product name
- Pimelic Diphenylamide 106
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $441
- Updated
- 2024/03/01
TC-H 106 Chemical Properties,Usage,Production
Description
Pimelic diphenylamide 106 is a slow, tight-
Uses
TC-H 106 is a slow, tight-binding inhibitor of class I histone deacetylases.
Definition
ChEBI: N'-(2-aminophenyl)-N-(4-methylphenyl)heptanediamide is an aromatic amine and an aromatic amide.
General Description
A cell-permeable p-tolylbenzamide and a Histone Deacetylase (HDAC) Inhibitor IV (Cat. No. 382170) analog that acts as a selective inhibitor against class I HDAC1,2,3 (IC50 = 0.15, 0.76, and 0.37 μM with 15, 30, and 180 min preincubation, respectively), while exhibiting much lower acitivity against class I HDAC8 (IC50 ≥ 5μM with 3 h preincubation) and no activity against class II HDAC4/5/7 even at concentrations as high as 180μM. Although the mode of inhibition is mechanistically competitive and reversible, due to the slow- and tight-binding nature, long preincubation is often required for effective in vitro enzyme inhibition, while 106-induced cellular H3 hyperacetylation is shown to persist for more than 6 hours after inhibitor removal by washing in GM15850 culture. 106 is reported to be less cytotoxic than TSA (Cat. No. 647925), MS-275, and SAHA (EC50 = 6.3, 0.328, 0.768, and 1.5 μM, respectively, in GM15850 killing).
Biochem/physiol Actions
Pimelic diphenylamides has the ability to enhance the expression of the frataxin gene in lymphocytes from Friedreich ataxia patients.
storage
-20°C
References
[1]. chou cj, herman d, gottesfeld jm. pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class i histone deacetylases. j biol chem, 2008, 283(51): 35402-35409.
[2]. xu c, soragni e, chou cj, et al. chemical probes identify a role for histone deacetylase 3 in friedreich's ataxia gene silencing. chem biol, 2009, 16(9): 980-989.
[3]. rai m, soragni e, jenssen k, et al. hdac inhibitors correct frataxin deficiency in a friedreich ataxia mouse model. plos one, 2008, 3(4): e1958.
TC-H 106 Preparation Products And Raw materials
Raw materials
Preparation Products
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