ChemicalBook > CAS DataBase List > (S)-1-(2-CHLOROPHENYL)ETHANOL

(S)-1-(2-CHLOROPHENYL)ETHANOL

Product Name
(S)-1-(2-CHLOROPHENYL)ETHANOL
CAS No.
131864-71-6
Chemical Name
(S)-1-(2-CHLOROPHENYL)ETHANOL
Synonyms
(S)-1-(2-chlorophenyl)ethane;(S)-1-(2-CHLOROPHENYL)ETHANOL;(S)-1-(2-chlorophenyl)ethan-1-ol;(S)-2' chloro-alphaMethylbenzylalcohol;(S)-1-(2-chlorophenyl)ethanol(WXC09851);BenzeneMethanol, 2-chloro-α-Methyl-, (αS)-;(S)-1-(2-Chlorophenyl)ethanol, 98% (colorless) liquid;(S)-1-(2-CHLOROPHENYL)ETHANOL,(S)-1-(2-CHLOROPHENYL)ETHANOL
CBNumber
CB5254091
Molecular Formula
C8H9ClO
Formula Weight
156.61
MOL File
131864-71-6.mol
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(S)-1-(2-CHLOROPHENYL)ETHANOL Property

Boiling point:
231℃
Density 
1.182
Flash point:
94℃
storage temp. 
Sealed in dry,Room Temperature
pka
14.05±0.20(Predicted)
Appearance
Colorless to light yellow Liquid
Water Solubility 
Slightly soluble in water.
InChI
InChI=1/C8H9ClO/c1-6(10)7-4-2-3-5-8(7)9/h2-6,10H,1H3/t6-/s3
InChIKey
DDUBOVLGCYUYFX-ISZMHOAENA-N
SMILES
C1(C=CC=CC=1Cl)[C@H](C)O |&1:7,r|
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Safety

HS Code 
2906290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

TRC
Product number
C992580
Product name
(S)-1-(2-Chlorophenyl)ethanol
Packaging
50mg
Price
$45
Updated
2021/12/16
Ark Pharm
Product number
P000038690
Product name
(S)-1-(2-Chlorophenyl)ethanol
Purity
98%
Packaging
1g
Price
$114
Updated
2021/12/16
ChemScene
Product number
CS-B0639
Product name
Benzenemethanol,2-chloro-α-methyl-,(αS)-
Packaging
1g
Price
$127
Updated
2021/12/16
Ark Pharm
Product number
P000038690
Product name
(S)-1-(2-Chlorophenyl)ethanol
Purity
98%
Packaging
100mg
Price
$20
Updated
2021/12/16
Ark Pharm
Product number
P000038690
Product name
(S)-1-(2-Chlorophenyl)ethanol
Purity
98%
Packaging
250mg
Price
$38
Updated
2021/12/16
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(S)-1-(2-CHLOROPHENYL)ETHANOL Chemical Properties,Usage,Production

Uses

It is an intermediate in organic syntheses and used as a pharmaceutical intermediates.

Synthesis

13524-04-4

13524-04-4

General procedure for the synthesis of 1-(2-chlorophenyl)ethanol from 1-(2-chlorophenyl)ethanol: Racemic alcohol (1o, 1.0 mmol) was dissolved in 5 mL of dichloromethane at -30 °C, and a compound of formula 2 (where R is I and n=2, and pharmaceutically acceptable salts thereof, 0.01 mol/mol) was added as catalyst. Subsequently, 0.7 equivalents of the methylsilylating agent Formula 5 (where R4 is methyl), 1 equivalent of potassium fluoride, and 80 mg of carboxylic acid-based ion exchange resin were added and the reaction mixture was stirred for 1 hour. Upon completion of the reaction, the mixture was filtered to recover the potassium fluoride and the ion exchange resin, and the filtrate was subsequently concentrated. The residue was purified by fast chromatography (eluent ratio acetone/hexane/triethylamine = 1:5:0.025) to afford the target product chiral alcohol (49% yield, enantiomeric excess value 98% ee, (S)-configuration).

References

[1] Patent: KR2015/114167, 2015, A. Location in patent: Paragraph 0359-0360
[2] Patent: KR2015/114445, 2015, A. Location in patent: Paragraph 0354; 0355; 0356; 0442
[3] Bulletin of the Chemical Society of Japan, 1996, vol. 69, # 4, p. 1079 - 1085
[4] Journal of the Chemical Society - Perkin Transactions 1, 1999, # 16, p. 2397 - 2402
[5] ChemCatChem, 2015, vol. 7, # 24, p. 4016 - 4020

(S)-1-(2-CHLOROPHENYL)ETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-(2-CHLOROPHENYL)ETHANOL Suppliers

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View Lastest Price from (S)-1-(2-CHLOROPHENYL)ETHANOL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
(1S)-1-(2-Chlorophenyl)ethanol 131864-71-6
Price
US $1.10-9.90/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100kg
Release date
2025-08-18
Career Henan Chemical Co
Product
(S)-1-(2-CHLOROPHENYL)ETHANOL 131864-71-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
150KG
Release date
2019-07-09

131864-71-6, (S)-1-(2-CHLOROPHENYL)ETHANOLRelated Search:

3,4,5,6-TETRACHLOROFLUORESCEIN (S)-(-)-4-(2-CHLOROPHENYL)-2-HYDROXY-5,5-DIMETHYL-1,3,2-DIOXAPHOSPHORINANE 2-OXIDE Demeclocycline hydrochloride CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL ROSE BENGAL Ketoconazole Isochlortetracyclinehydrochloride 2',4',5',7'-TETRABROMO-3,4,5,6-TETRACHLOROFLUORESCEIN Chlortetracycline hydrochloride ROSE BENGAL (+/-)-ETHYL-CIS-[4-[[2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]-METHYLTHIO]PHENYL]-CARBAMATE HYDROCHLORIDE 2,2'-DICHLOROBENZILIC ACID Acid Red 92 1,1-BIS(4-CHLOROPHENYL)ETHANOL,chlorfenethol (ISO) 1,1-bis (4-chlorophenyl) ethanol alpha-(o-Chlorophenyl)ethanol,1-(o-Chlorophenyl)ethanol,1-(2-CHLOROPHENYL)ETHANOL 2-(O-CHLOROPHENYL)ETHANOL (S)-2-Amino-1-(3-chlorophenyl)ethanol hydrochloride 1-(4-CHLOROPHENYL)ETHANOL,1-(p-Chlorophenyl)ethanol,alpha-(p-Chlorophenyl)ethanol

  • (S)-1-(2-CHLOROPHENYL)ETHANOL
  • (S)-2' chloro-alphaMethylbenzylalcohol
  • BenzeneMethanol, 2-chloro-α-Methyl-, (αS)-
  • (S)-1-(2-CHLOROPHENYL)ETHANOL,(S)-1-(2-CHLOROPHENYL)ETHANOL
  • (S)-1-(2-Chlorophenyl)ethanol, 98% (colorless) liquid
  • (S)-1-(2-chlorophenyl)ethanol(WXC09851)
  • (S)-1-(2-chlorophenyl)ethane
  • (S)-1-(2-chlorophenyl)ethan-1-ol
  • 131864-71-6
  • chiral
  • Chiral Reagent