GSK269962A

ChemicalBook > CAS DataBase List > GSK269962A

Product Name: GSK269962A
CAS No.: 850664-21-0
Chemical Name: GSK269962A
Synonyms: CS-1126;GSK269962B;GSK 269962;GSK-269962 95%;GSK269962A(GSK269962);GSK269962 (GSK269962A);GSK269962A/GSK 269962A;ROCK inhibitor GS269962A;ROCK inhibitor GSK269962A;GSK269962A ISO 9001：2015 REACH
CBNumber: CB52546776
Molecular Formula: C29H30N8O5
Formula Weight: 570.6
MOL File: 850664-21-0.mol

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GSK269962A Property

Melting point:: 125 - 127°C
Density: 1.45
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 13.19±0.70(Predicted)
color: Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19180
Product name: GSK269962
Purity: ≥95%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 19180
Product name: GSK269962
Purity: ≥95%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 19180
Product name: GSK269962
Purity: ≥95%
Packaging: 10mg
Price: $283
Updated: 2024/03/01

Cayman Chemical

Product number: 19180
Product name: GSK269962
Purity: ≥95%
Packaging: 25mg
Price: $618
Updated: 2024/03/01

Tocris

Product number: 4009
Product name: GSK269962
Purity: ≥99%(HPLC)
Packaging: 10
Price: $292
Updated: 2021/12/16

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GSK269962A Chemical Properties,Usage,Production

Description

Two Rho-associated kinases (ROCKS), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. GSK269962 is a selective ROCK inhibitor with IC₅₀ values of 1.6 and 6 nM for ROCK1 and ROCK2, respectively. It displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. GSK269962 has been shown to block the generation of inflammatory cytokines in lipopolysaccharide-stimulated monocytes and to induce vasorelaxation in preconstricted rat aorta (IC₅₀ = 35 nM). Oral administration of 1-30 mg/kg GSK269962 can dose-dependently lower blood pressure in spontaneously hypertensive rats.

Uses

GSK 269962 is a potent and selective Rho kinase (ROCK) inhibitor.

storage

Store at +4°C

GSK269962A Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK269962A Suppliers

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View Lastest Price from GSK269962A manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: GSK269962A 850664-21-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-04-30

Career Henan Chemical Co

Product: N-(3-{[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c] pyridin-6-yl]oxy}phenyl)-4-[2-(4-morpholinyl)ethoxy]benzamide 850664-21-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

850664-21-0, GSK269962ARelated Search:

GSK 269962

N-[3-[[2-(4-Aminofurazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[[2-(4-morpholinyl)ethyl]oxy]benzamide

GSK269962A(GSK269962)

N-(3-((2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl)oxy)phenyl)-4-(2-morpholinoethoxy)benzamide

CS-1126

N-[3-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]benzamide

ROCK inhibitor GS269962A

GSK 269962A;GSK-269962A;GSK269962;GSK 269962;GSK-269962

GSK269962B

GSK-269962 95%

ROCK inhibitor GSK269962A

GSK269962A ISO 9001：2015 REACH

GSK269962 (GSK269962A)

anti-inflammatory,ROCK,pressure,blood,antihypertensive,Rho-associated protein kinase,Inhibitor,GSK-269962,Rho-associated kinase,ROK,ROCK2,inhibit,GSK-269962A,GSK269962,vasodilatory,Rho-kinase,GSK269962A,ROCK1,cardiovascular

GSK269962A/GSK 269962A

850664-21-0