N-(5-BroMothiazolo[5,4-b]pyridin-2-yl)acetaMide
- Product Name
- N-(5-BroMothiazolo[5,4-b]pyridin-2-yl)acetaMide
- CAS No.
- 1112982-76-9
- Chemical Name
- N-(5-BroMothiazolo[5,4-b]pyridin-2-yl)acetaMide
- Synonyms
- N-(5-Bromothiazolo[5,4-b]pyridin-2-yl);N-(5-BroMothiazolo[5,4-b]pyridin-2-yl)acetaMide;Acetamide, N-(5-bromothiazolo[5,4-b]pyridin-2-yl)-
- CBNumber
- CB52549919
- Molecular Formula
- C8H6BrN3OS
- Formula Weight
- 272.12
- MOL File
- 1112982-76-9.mol
N-(5-BroMothiazolo[5,4-b]pyridin-2-yl)acetaMide Property
- Density
- 1.829±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.20±0.43(Predicted)
- InChI
- InChI=1S/C8H6BrN3OS/c1-4(13)10-8-11-5-2-3-6(9)12-7(5)14-8/h2-3H,1H3,(H,10,11,13)
- InChIKey
- JHGFPKWDFAFFFO-UHFFFAOYSA-N
- SMILES
- C(NC1=NC2=CC=C(Br)N=C2S1)(=O)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B680228
- Product name
- N-(5-Bromothiazolo[5,4-b]pyridin-2-yl)acetamide
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B680228
- Product name
- N-(5-Bromothiazolo[5,4-b]pyridin-2-yl)acetamide
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- HCH0143882
- Product name
- N-(5-BROMOTHIAZOLO[5,4-BETA]PYRIDIN-2-YL)ACETAMIDE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $200.55
- Updated
- 2021/12/16
- Product number
- X8973
- Product name
- N-(5-Bromothiazolo[5,4-b]pyridin-2-yl)acetamide
- Packaging
- 1g
- Price
- $228
- Updated
- 2021/12/16
- Product number
- 074635
- Product name
- N-(5-Bromothiazolo[5,4-b]pyridin-2-yl)acetamide
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $537
- Updated
- 2021/12/16
N-(5-BroMothiazolo[5,4-b]pyridin-2-yl)acetaMide Chemical Properties,Usage,Production
Synthesis
934266-82-7
108-24-7
1112982-76-9
Example 1: Potassium thiocyanate (42.1 g, 433 mmol) was added to a 500 mL three-necked flask under nitrogen protection, followed by 225 mL of acetic acid. The mixture was cooled to -5 °C and 6-bromo-3-aminopyridine (15 g, 86.7 mmol) was added in batches. Further cooled to -15°C, a solution of bromine (5.7 mL) in 12 mL of acetic acid was added dropwise while controlling the bath temperature below 10°C. Slowly warm to room temperature and stir overnight. A small amount of precipitate was removed by filtration. The mother liquor was cooled to 0 °C, water (200 mL) was added, and after stirring for 5 min, the precipitate was collected and washed with cold methanol/ether (1:3, 50 mL, 2 times). The solid was dried overnight under vacuum to give 5-bromothiazolo[5,4-b]pyridin-2-amine (10.2 g, 51%). The filtrate was concentrated to half the original volume, the precipitate was collected, washed with cold methanol-ether and dried to give 2 g of additional product in a total yield of 12.2 g (61% yield). To a solution of pyridine (88 mL) of the above product (11.3 g, 40 mmol) was slowly added ethanoic anhydride (44 mL) at 0 °C and stirred for 16 h at room temperature. The solvent was removed and the residue was dried under vacuum for 20 h to give N-(5-bromothiazolo[5,4-b]pyridin-2-yl)acetamide (13.3 g, 100%) as a light brown solid. Mass spectrometry analysis: [M + H] C8H6BrN3OS calculated value 272, measured value 272.
References
[1] Patent: WO2010/8847, 2010, A2. Location in patent: Page/Page column 123
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 14, p. 3739 - 3748
N-(5-BroMothiazolo[5,4-b]pyridin-2-yl)acetaMide Preparation Products And Raw materials
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