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3,4-Dichloro-6-fluoroaniline

Product Name
3,4-Dichloro-6-fluoroaniline
CAS No.
2729-36-4
Chemical Name
3,4-Dichloro-6-fluoroaniline
Synonyms
4,5-Dichloro-2-fluoroaniline;3,4-Dichloro-6-fluoroaniline;3,4-Dichloro-6-fluoroaniline,96%;Benzenamine, 4,5-dichloro-2-fluoro-;4,5-dichloro-2-fluoroaniline hydrochloride
CBNumber
CB52550207
Molecular Formula
C6H4Cl2FN
Formula Weight
180.01
MOL File
2729-36-4.mol
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3,4-Dichloro-6-fluoroaniline Property

Boiling point:
251.8±35.0 °C(Predicted)
Density 
1.502±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
1.51±0.10(Predicted)
Appearance
Off-white to gray Solid
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Safety

HazardClass 
6.1
HS Code 
2921420090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
D437465
Product name
4,5-Dichloro-2-fluoroaniline
Packaging
25g
Price
$75
Updated
2021/12/16
AK Scientific
Product number
2562AB
Product name
4,5-Dichloro-2-fluoroaniline
Packaging
250mg
Price
$335
Updated
2021/12/16
AK Scientific
Product number
2562AB
Product name
4,5-Dichloro-2-fluoroaniline
Packaging
1g
Price
$335
Updated
2021/12/16
SynQuest Laboratories
Product number
3630-7-77
Product name
4,5-Dichloro-2-fluoroaniline
Packaging
1g
Price
$386
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0365297
Product name
4,5-DICHLORO-2-FLUOROANILINE
Purity
95.00%
Packaging
5MG
Price
$502.13
Updated
2021/12/16
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3,4-Dichloro-6-fluoroaniline Chemical Properties,Usage,Production

Uses

3,4-Dichloro-6-fluoroaniline is used as pharmaceutical intermediates

Synthesis

2339-78-8

2729-36-4

To a 100 mL three-necked round-bottomed flask treated with an inert atmosphere under nitrogen protection was added iron powder (14 g, 250.00 mmol, 10.50 equiv), acetic acid (1.5 mL) and water (24 mL). The mixture was heated to 100 °C and then 1,2-dichloro-4-fluoro-5-nitrobenzene (5 g, 23.81 mmol, 1.00 eq.) was slowly added. The reaction mixture was stirred continuously at 100 °C for 30 min. Subsequently, the reaction solution was cooled to 10 °C using an ice-water bath and the pH was adjusted to 8-9 with saturated aqueous sodium bicarbonate. the solid insoluble material was removed by filtration, the filtrate was extracted with ether (3 x 40 mL), the organic phases were combined, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. Finally, 4.2 g (98% yield) of 4,5-dichloro-2-fluoroaniline was obtained as a white solid.

References

[1] Patent: WO2012/125913, 2012, A1. Location in patent: Page/Page column 42; 43
[2] Journal of the American Chemical Society, 1959, vol. 81, p. 94,95, 97
[3] Journal of Labelled Compounds and Radiopharmaceuticals, 1999, vol. 42, # SUPPL. 1, p. S27-S29
[4] Patent: US2009/48109, 2009, A1. Location in patent: Page/Page column 7

3,4-Dichloro-6-fluoroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-Dichloro-6-fluoroaniline Suppliers

Canada 1 China 30 India 2 United Kingdom 2 United States 4 Global 39
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
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View Lastest Price from 3,4-Dichloro-6-fluoroaniline manufacturers

Career Henan Chemical Co
Product
3,4-Dichloro-6-fluoroaniline 2729-36-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-14

2729-36-4, 3,4-Dichloro-6-fluoroanilineRelated Search:


  • 3,4-Dichloro-6-fluoroaniline
  • 4,5-Dichloro-2-fluoroaniline
  • Benzenamine, 4,5-dichloro-2-fluoro-
  • 3,4-Dichloro-6-fluoroaniline,96%
  • 4,5-dichloro-2-fluoroaniline hydrochloride
  • 2729-36-4