ethyl 3,5-diaMino-1H-pyrazole-4-carboxylate
- Product Name
- ethyl 3,5-diaMino-1H-pyrazole-4-carboxylate
- CAS No.
- 6825-71-4
- Chemical Name
- ethyl 3,5-diaMino-1H-pyrazole-4-carboxylate
- Synonyms
- 100084;EOS-61556;3,5-Diamino-4-ethoxycarbonylpyrazole;Ethyl 3,5-diamino-4-pyrazolecarboxylate;ethyl 3,5-diami-1H-pyrazole-4-carboxylate;Ethyl 3,5-diamino-4-pyrazoxycarboxylic acid;ethyl 3,5-diaMino-1H-pyrazole-4-carboxylate;3,5-Diamino-1H-pyrazole-4-carboxylic acid ethyl ester;1H-Pyrazole-4-carboxylic acid, 3,5-diamino-, ethyl ester
- CBNumber
- CB52552751
- Molecular Formula
- C6H10N4O2
- Formula Weight
- 170.17
- MOL File
- 6825-71-4.mol
ethyl 3,5-diaMino-1H-pyrazole-4-carboxylate Property
- Melting point:
- 189-190℃
- Boiling point:
- 419.4±40.0 °C(Predicted)
- Density
- 1.418±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 14.26±0.50(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C6H10N4O2/c1-2-12-6(11)3-4(7)9-10-5(3)8/h2H2,1H3,(H5,7,8,9,10)
- InChIKey
- HRAWNPOJGRIJSB-UHFFFAOYSA-N
- SMILES
- N1C(N)=C(C(OCC)=O)C(N)=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 071136
- Product name
- Ethyl 3,5-diamino-1H-pyrazole-4-carboxylate
- Purity
- 97%
- Packaging
- 500mg
- Price
- $230
- Updated
- 2021/12/16
- Product number
- 071136
- Product name
- Ethyl 3,5-diamino-1H-pyrazole-4-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 0520AC
- Product name
- Ethyl3,5-diamino-1H-pyrazole-4-carboxylate
- Packaging
- 250mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 071136
- Product name
- Ethyl 3,5-diamino-1H-pyrazole-4-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $1050
- Updated
- 2021/12/16
- Product number
- 6825714
- Product name
- Ethyl3,5-diamino-1H-pyrazole-4-carboxylate
- Packaging
- 25g
- Price
- $1548.4
- Updated
- 2021/12/16
ethyl 3,5-diaMino-1H-pyrazole-4-carboxylate Chemical Properties,Usage,Production
Uses
Ethyl 3,5-diaMino-1H-pyrazole-4-carboxylate belongs to carboxylic acid ester derivatives, which can be used as pharmaceutical intermediates and used in medical experimental research.
Synthesis
49765-05-1
6825-71-4
General procedure for the synthesis of ethyl 3,5-diamino-1H-pyrazole-4-carboxylate from ethyl (Z)-3-amino-4,4,4-trichloro-2-cyano-but-2-enoate: hydrazine (2.19 mL, 70 mmol) was added to ethyl (Z)-3-amino-4,4,4-trichloro-2-cyano-but-2-enoate (15.0 g, 58 mmol) in DMF (50 mL) solution. The reaction mixture was heated to 100 °C and kept for 1 h, followed by cooling to room temperature. The DMF was removed under vacuum and the residue was slurried in a 95:5 (v/v) mixture of DCM and 2 M methanol ammonia solution. The resulting precipitate was collected by filtration, washed with a 95:5 mixture of DCM:MeOH and dried under vacuum to afford 5.72 g (58% yield) of ethyl 3,5-diamino-1H-pyrazole-4-carboxylate as a white solid.1H NMR (400 MHz, DMSO) δ 10.53 (s, 1H), 5.28 (br, 4H), 4.14 (q, J = 7.1 Hz, 2H), 1.33-1.15 (t, J = 7.1 Hz, 3H).
References
[1] Patent: WO2015/73267, 2015, A1. Location in patent: Paragraph 317; 367
[2] Patent: CN104650092, 2017, B. Location in patent: Paragraph 0463-0464; 0469-0470
[3] Patent: CN108003161, 2018, A. Location in patent: Paragraph 0849; 0855-0857
[4] Patent: WO2011/3065, 2011, A2. Location in patent: Page/Page column 110
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View Lastest Price from ethyl 3,5-diaMino-1H-pyrazole-4-carboxylate manufacturers
- Product
- ethyl 3,5-diaMino-1H-pyrazole-4-carboxylate 6825-71-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-02