(6-(difluoroMethoxy)pyridin-3-yl)MethanaMine

Product Name: (6-(difluoroMethoxy)pyridin-3-yl)MethanaMine
CAS No.: 1198103-43-3
Chemical Name: (6-(difluoroMethoxy)pyridin-3-yl)MethanaMine
Synonyms: 6-(Difluoromethoxy)-3-pyridinemethanamine;3-Pyridinemethanamine, 6-(difluoromethoxy)-;(6-(difluoroMethoxy)pyridin-3-yl)MethanaMine;(6-(Difluoromethoxy)pyridin-3-yl)methanamine - [D71646]
CBNumber: CB52553662
Molecular Formula: C7H8F2N2O
Formula Weight: 174.15
MOL File: 1198103-43-3.mol

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(6-(difluoroMethoxy)pyridin-3-yl)MethanaMine Property

Boiling point:: 234.5±35.0 °C(Predicted)
Density: 1.262±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 7.87±0.29(Predicted)
Appearance: Colorless to light yellow Liquid

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: D452673
Product name: (6-(Difluoromethoxy)pyridin-3-yl)methanamine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: PC201048
Product name: (6-(Difluoromethoxy)pyridin-3-yl)methanamine
Purity: 97%
Packaging: 100mg
Price: $113
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0368056
Product name: (6-(DIFLUOROMETHOXY)PYRIDIN-3-YL)METHANAMINE
Purity: 95.00%
Packaging: 5MG
Price: $502.16
Updated: 2021/12/16

Chemenu

Product number: CM175071
Product name: (6-(Difluoromethoxy)pyridin-3-yl)methanamine
Purity: 97%
Packaging: 1g
Price: $443
Updated: 2021/12/16

Crysdot

Product number: CD11333940
Product name: (6-(Difluoromethoxy)pyridin-3-yl)methanamine
Purity: 97%
Packaging: 1g
Price: $469
Updated: 2021/12/16

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(6-(difluoroMethoxy)pyridin-3-yl)MethanaMine Chemical Properties,Usage,Production

Synthesis

1198103-42-2

1198103-43-3

General procedure for the synthesis of 6-(difluoromethoxy)pyridine-3-carbonitrile from 6-(difluoromethoxy)pyridine-3-methanamine: Raney nickel (150 mg) was added to a solution of 6-(difluoromethoxy)nicotinonitrile (0.541 g, 3.18 mmol) in methanol (20 mL, saturated with ammonia). The reaction mixture was hydrogenated at room temperature under 45 psi hydrogen pressure for 20 hours. Upon completion of the reaction, the reaction mixture was filtered through a short bed of diatomaceous earth and the filtrate was concentrated under vacuum. The crude product was purified by silica gel column chromatography using dichloromethane:methanol=90:10 as eluent to afford 6-difluoromethoxypyridine-3-methanamine as a light yellow oil in a yield of 440 mg (80% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.12 (d, 1H), 7.73 (dd, 1H), 7.45 (t, 1H), 6.88 (d, 1H), 3.88 (s, 2H) (NH2 not shown); 19F NMR (400 MHz, CDCl3) δ -88.98 and -89.17; MS ( ESI) m/z 175 [M + H]+.

References

[1] Patent: WO2009/145720, 2009, A1. Location in patent: Page/Page column 29
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 15, p. 6866 - 6880

(6-(difluoroMethoxy)pyridin-3-yl)MethanaMine Preparation Products And Raw materials

Raw materials

Preparation Products

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(6-(difluoroMethoxy)pyridin-3-yl)MethanaMine Suppliers

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1198103-43-3, (6-(difluoroMethoxy)pyridin-3-yl)MethanaMineRelated Search:

(6-(difluoroMethoxy)pyridin-3-yl)MethanaMine

3-Pyridinemethanamine, 6-(difluoromethoxy)-

6-(Difluoromethoxy)-3-pyridinemethanamine

(6-(Difluoromethoxy)pyridin-3-yl)methanamine - [D71646]

1198103-43-3