Refametinib
- Product Name
- Refametinib
- CAS No.
- 923032-37-5
- Chemical Name
- Refametinib
- Synonyms
- CS-2434;RDEA119;BAY-869766;RefaMetinib;BAY 8697661;RDEA119 USP/EP/BP;REFAMETINIB(RDEA119);RDEA-119 (BAY-869766);Acrylamide Impurity 13;BAY 869766; BAY 86-9766
- CBNumber
- CB52561494
- Molecular Formula
- C19H20F3IN2O5S
- Formula Weight
- 572.34
- MOL File
- 923032-37-5.mol
Refametinib Property
- Boiling point:
- 566.9±60.0 °C(Predicted)
- Density
- 1.82±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥151.8 mg/mL in DMSO; ≥90.2 mg/mL in EtOH
- form
- Powder
- pka
- 15.54±0.20(Predicted)
- color
- White to yellow
Safety
- HS Code
- 2935909099
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P314Get medical advice/attention if you feel unwell.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 16997
- Product name
- Refametinib
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $38
- Updated
- 2024/03/01
- Product number
- 16997
- Product name
- Refametinib
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $111
- Updated
- 2024/03/01
- Product number
- 16997
- Product name
- Refametinib
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 16997
- Product name
- Refametinib
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $547
- Updated
- 2024/03/01
- Product number
- 464562
- Product name
- Refametinib
- Packaging
- 1mg
- Price
- $312
- Updated
- 2021/12/16
Refametinib Chemical Properties,Usage,Production
Description
Lorlatinib (PF-06463922, Pfizer Oncology, Groton, CT, USA) is an oral TKI that targets both ALK and ROS1 with high affinity and good CNS penetration [91].
Uses
Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2. Potent MEK inhibitor.
Clinical Use
Lorlatinib is the sole third-generation ALK inhibitor at this time; it is approved for ALK-positive NSCLC patients who progressed on at least two ALK inhibitors with one being crizotinib or who progressed on alectinib or ceritinib if either is used in the frontline setting.
target
MEK1
References
[1] iverson c, larson g, lai c, et al. rdea119/bay 869766: a potent, selective, allosteric inhibitor of mek1/2 for the treatment of cancer. cancer research, 2009, 69(17): 6839-6847.
Refametinib Preparation Products And Raw materials
Raw materials
Preparation Products
Refametinib Suppliers
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- 86-21-57758967
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- China
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- United States
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View Lastest Price from Refametinib manufacturers
- Product
- Refametinib 923032-37-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Refametinib 923032-37-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09