Methyl 2-(5-broMopyridin-2-yl)acetate

Product Name: Methyl 2-(5-broMopyridin-2-yl)acetate
CAS No.: 917023-06-4
Chemical Name: Methyl 2-(5-broMopyridin-2-yl)acetate
Synonyms: Methyl 5-broMopyridine-2-acetate;Methyl 2-(5-bromo-2-pyridyl)acetate;Methyl 2-(5-broMopyridin-2-yl)acetate;(5-BroMo-2-pyridinyl)acetic acid Methyl ester;2-Pyridineacetic acid, 5-bromo-, methyl ester
CBNumber: CB52563337
Molecular Formula: C8H8BrNO2
Formula Weight: 230.06
MOL File: 917023-06-4.mol

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Methyl 2-(5-broMopyridin-2-yl)acetate Property

Boiling point:: 266.0±25.0 °C(Predicted)
Density: 1.517±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 1.95±0.22(Predicted)
Appearance: White to yellow Solid
InChI: InChI=1S/C8H8BrNO2/c1-12-8(11)4-7-3-2-6(9)5-10-7/h2-3,5H,4H2,1H3
InChIKey: NIAATLPQSKGUBG-UHFFFAOYSA-N
SMILES: C1(CC(OC)=O)=NC=C(Br)C=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHB00159
Product name: Methyl 5-bromopyridine-2-acetate
Purity: AldrichCPR
Packaging: 1 g
Price: $179
Updated: 2025/07/31

TRC

Product number: M296568
Product name: Methyl2-(5-Bromopyridin-2-yl)acetate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M296568
Product name: Methyl2-(5-Bromopyridin-2-yl)acetate
Packaging: 500mg
Price: $155
Updated: 2021/12/16

AK Scientific

Product number: 1610DL
Product name: Methyl2-(5-bromopyridin-2-YL)acetate
Packaging: 250mg
Price: $116
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-9-0X
Product name: Methyl 2-(5-bromopyridin-2-yl)acetate
Purity: 97.0%
Packaging: 1g
Price: $490
Updated: 2021/12/16

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Methyl 2-(5-broMopyridin-2-yl)acetate Chemical Properties,Usage,Production

Synthesis

192642-83-4

18107-18-1

917023-06-4

5-(5-Bromo-1H-2-pyridinyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione (4.53 g, 15.09 mmol) was used as a starting material and dissolved in dioxane (20 mL). Concentrated hydrochloric acid (10 mL) was added to this solution and the mixture was subsequently stirred at 100 °C for 1 hour. Upon completion of the reaction, the mixture was cooled and concentrated under reduced pressure. The concentrated residue was dissolved in a solvent mixture of methanol (20 mL) and toluene (20 mL). To this solution was added trimethylsilylated diazomethane (2M ethyl ether solution, 25 mL) and stirred for 30 minutes at room temperature. Reaction termination was achieved by addition of acetic acid. Subsequently, the reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 100:0 to 30:70, 40 min) to afford the target product methyl 2-(5-bromopyridin-2-yl)acetate as a colorless oil (2.50 g, 72% yield). The product was characterized by 1H-NMR (chloroform-d): δ 3.73 (3H, s), 3.82 (2H, s), 7.21 (1H, d, J=8.24 Hz), 7.79 (1H, dd, J=8.25,2.31 Hz), 8.62 (1H, d, J=2.31 Hz).

References

[1] Patent: EP1894911, 2008, A1. Location in patent: Page/Page column 82

Methyl 2-(5-broMopyridin-2-yl)acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl 2-(5-broMopyridin-2-yl)acetate manufacturers

Career Henan Chemical Co

Product: Methyl 2-(5-bromopyridin-2-yl)acetate 917023-06-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

917023-06-4, Methyl 2-(5-broMopyridin-2-yl)acetateRelated Search:

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Methyl 2-(5-bromo-2-pyridyl)acetate

Methyl 2-(5-broMopyridin-2-yl)acetate

(5-BroMo-2-pyridinyl)acetic acid Methyl ester

Methyl 5-broMopyridine-2-acetate

917023-06-4