Methyl 2-(5-broMopyridin-2-yl)acetate
- Product Name
- Methyl 2-(5-broMopyridin-2-yl)acetate
- CAS No.
- 917023-06-4
- Chemical Name
- Methyl 2-(5-broMopyridin-2-yl)acetate
- Synonyms
- Methyl 5-broMopyridine-2-acetate;Methyl 2-(5-bromo-2-pyridyl)acetate;Methyl 2-(5-broMopyridin-2-yl)acetate;(5-BroMo-2-pyridinyl)acetic acid Methyl ester;2-Pyridineacetic acid, 5-bromo-, methyl ester
- CBNumber
- CB52563337
- Molecular Formula
- C8H8BrNO2
- Formula Weight
- 230.06
- MOL File
- 917023-06-4.mol
Methyl 2-(5-broMopyridin-2-yl)acetate Property
- Boiling point:
- 266.0±25.0 °C(Predicted)
- Density
- 1.517±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 1.95±0.22(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C8H8BrNO2/c1-12-8(11)4-7-3-2-6(9)5-10-7/h2-3,5H,4H2,1H3
- InChIKey
- NIAATLPQSKGUBG-UHFFFAOYSA-N
- SMILES
- C1(CC(OC)=O)=NC=C(Br)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PHB00159
- Product name
- Methyl 5-bromopyridine-2-acetate
- Purity
- AldrichCPR
- Packaging
- 1 g
- Price
- $179
- Updated
- 2025/07/31
- Product number
- M296568
- Product name
- Methyl2-(5-Bromopyridin-2-yl)acetate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M296568
- Product name
- Methyl2-(5-Bromopyridin-2-yl)acetate
- Packaging
- 500mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 1610DL
- Product name
- Methyl2-(5-bromopyridin-2-YL)acetate
- Packaging
- 250mg
- Price
- $116
- Updated
- 2021/12/16
- Product number
- 1610DL
- Product name
- Methyl2-(5-bromopyridin-2-YL)acetate
- Packaging
- 1g
- Price
- $184
- Updated
- 2021/12/16
Methyl 2-(5-broMopyridin-2-yl)acetate Chemical Properties,Usage,Production
Synthesis
192642-83-4
18107-18-1
917023-06-4
5-(5-Bromo-1H-2-pyridinyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione (4.53 g, 15.09 mmol) was used as a starting material and dissolved in dioxane (20 mL). Concentrated hydrochloric acid (10 mL) was added to this solution and the mixture was subsequently stirred at 100 °C for 1 hour. Upon completion of the reaction, the mixture was cooled and concentrated under reduced pressure. The concentrated residue was dissolved in a solvent mixture of methanol (20 mL) and toluene (20 mL). To this solution was added trimethylsilylated diazomethane (2M ethyl ether solution, 25 mL) and stirred for 30 minutes at room temperature. Reaction termination was achieved by addition of acetic acid. Subsequently, the reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 100:0 to 30:70, 40 min) to afford the target product methyl 2-(5-bromopyridin-2-yl)acetate as a colorless oil (2.50 g, 72% yield). The product was characterized by 1H-NMR (chloroform-d): δ 3.73 (3H, s), 3.82 (2H, s), 7.21 (1H, d, J=8.24 Hz), 7.79 (1H, dd, J=8.25,2.31 Hz), 8.62 (1H, d, J=2.31 Hz).
References
[1] Patent: EP1894911, 2008, A1. Location in patent: Page/Page column 82
Methyl 2-(5-broMopyridin-2-yl)acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 2-(5-broMopyridin-2-yl)acetate Suppliers
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View Lastest Price from Methyl 2-(5-broMopyridin-2-yl)acetate manufacturers
- Product
- Methyl 2-(5-bromopyridin-2-yl)acetate 917023-06-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09