1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2h)-yl)ethanone

Application

Product Name: 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2h)-yl)ethanone
CAS No.: 1227068-67-8
Chemical Name: 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2h)-yl)ethanone
Synonyms: (1-ACETYL-1,2,3;N-acetyl-3,6-dihydro-2H-pyridine-4-boronic acid pinacol ester;1-Acetyl-5,6-dihydro-2H-pyridine-4-boronic acid, pinacol ester;1-Acetyl-1,2,3,6-tetrahydropyridine-4-boronic Acid Pinacol Ester;(1-ACETYL-1,2,3,6-TETRAHYDROPYRIDIN-4-YL)BORONIC ACID PINACOL ESTER;1-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridin-1-yl]ethan-1-one;1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinyl]ethanone;1-[3,6-Dihydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1(2H)-pyridinyl]ethanone;1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2h)-yl)ethanone;1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridin-1(2H)-yl)ethan-1-one
CBNumber: CB52563645
Molecular Formula: C13H22BNO3
Formula Weight: 251.13
MOL File: 1227068-67-8.mol

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1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2h)-yl)ethanone Property

Boiling point:: 329.2±52.0 °C(Predicted)
Density: 1.05±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: -0.34±0.40(Predicted)
Appearance: White to yellow Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Usbiological

Product number: 408690
Product name: 1-Acetyl-5,6-dihydro-2H-pyridine-4-boronic acid, pinacol ester
Packaging: 10mg
Price: $305
Updated: 2021/12/16

TRC

Product number: A179123
Product name: 1-Acetyl-5,6-dihydro-2H-pyridine-4-boronicacid,pinacolester
Packaging: 1g
Price: $495
Updated: 2021/12/16

ChemScene

Product number: CS-W019712
Product name: 1-[3,6-Dihydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1(2H)-pyridinyl]ethanone
Purity: >98.0%
Packaging: 250mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-W019712
Product name: 1-[3,6-Dihydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1(2H)-pyridinyl]ethanone
Purity: >98.0%
Packaging: 1g
Price: $138
Updated: 2021/12/16

AK Scientific

Product number: Z1883
Product name: 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2H)-yl)ethanone
Packaging: 250mg
Price: $146
Updated: 2021/12/16

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1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2h)-yl)ethanone Chemical Properties,Usage,Production

Application

1-Acetyl-5,6-dihydro-2H-pyridine-4-boronic acid pinacol ester can be used as an organic synthesis intermediate and a pharmaceutical intermediate in laboratory research and development processes and in the synthesis of pharmaceutical chemicals.

Synthesis

1121057-75-7

75-36-5

1227068-67-8

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine hydrochloride (Intermediate G3, 1.4 g, 5.70 mmol) was suspended in dichloromethane (DCM, 15 mL) and stirred at 0 °C. Subsequently, triethylamine (TEA, 2.384 mL, 17.10 mmol) and acetyl chloride (AcCl, 0.405 mL, 5.70 mmol) were sequentially added to the reaction system. The reaction mixture was gradually warmed to room temperature and stirring was continued for 30 minutes. Upon completion of the reaction, the reaction volume was concentrated to 1/3 of the initial volume and the residue was diluted with ethyl acetate (AcOEt, 150 mL). The organic phase was washed sequentially twice with water, once with 0.2 M aqueous hydrochloric acid, once with saturated aqueous sodium bicarbonate (NaHCO3) and finally dried over anhydrous sodium sulfate (Na2SO4). The solvent was removed under reduced pressure to give 1-acetyl-5,6-dihydro-2H-pyridine-4-boronic acid pinacol ester (1.24 g, 87% yield) as a pale yellow solid.UPLC-MS analysis resulted in a retention time of 0.83 min and a molecular ion peak of 252.3 [M+H]+, analytical method 9.

References

[1] Patent: WO2015/91685, 2015, A1. Location in patent: Page/Page column 139
[2] Patent: US2015/166549, 2015, A1. Location in patent: Paragraph 0861; 0862; 0863
[3] Patent: WO2011/143495, 2011, A1. Location in patent: Page/Page column 86

1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2h)-yl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2h)-yl)ethanone Suppliers

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View Lastest Price from 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2h)-yl)ethanone manufacturers

Henan Fengda Chemical Co., Ltd

Product: 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2h)-yl)ethanone 1227068-67-8
Price: US $34.00-1.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

Product: 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2h)-yl)ethanone 1227068-67-8
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 98%+
Supply Ability: 100kg
Release date: 2023-03-08

Career Henan Chemical Co

Product: 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2h)-yl)ethanone 1227068-67-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-07

1227068-67-8, 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2h)-yl)ethanoneRelated Search:

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1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2h)-yl)ethanone

1-Acetyl-5,6-dihydro-2H-pyridine-4-boronic acid, pinacol ester

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1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridin-1(2H)-yl)ethan-1-one

1227068-67-8

Organic boronic acid