Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate

Product Name: Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate
CAS No.: 478375-42-7
Chemical Name: Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate
Synonyms: Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxabo;Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);3-(2-Methoxy-2-oxoethyl)phenylboronic acid, pinacol ester;methyl 2-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate;Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate;3-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl-acetic acid Methyl ester;Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate - [M23835];Benzeneacetic acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester
CBNumber: CB52564192
Molecular Formula: C15H21BO4
Formula Weight: 276.14
MOL File: 478375-42-7.mol

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Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate Property

Boiling point:: 372.0±25.0 °C(Predicted)
Density: 1.07±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Colorless to light yellow Liquid

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Safety

HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Synthonix

Product number: M23835
Product name: Methyl2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate
Purity: 97%
Packaging: 1g
Price: $200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0007214
Product name: METHYL-2-(3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL)ACETATE
Purity: 95.00%
Packaging: 5MG
Price: $501.4
Updated: 2021/12/16

AK Scientific

Product number: X0829
Product name: 3-(2-Methoxy-2-oxoethyl)phenylboronicacidpinacolester
Packaging: 10g
Price: $1237
Updated: 2021/12/16

Alichem

Product number: 478375427
Product name: Methyl2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate
Packaging: 10g
Price: $846.29
Updated: 2021/12/16

Chemenu

Product number: CM136898
Product name: Methyl2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate
Purity: 95+%
Packaging: 5g
Price: $468
Updated: 2021/12/16

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Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate Chemical Properties,Usage,Production

Synthesis

150529-73-0

73183-34-3

478375-42-7

Step 1: Synthesis of methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate Methyl 2-(3-bromophenyl)acetate (5.00 g, 21.8 mmol), bis(pinacolato)diboron (11.1 g, 43.7 mmol), and potassium acetate (6.43 g, 65.5 mmol) were dissolved in dioxane (43.7 mL) and degassed by bubbling nitrogen. PdCl2 (dppf)-CH2Cl2 adduct (0.446 g, 0.546 mmol) was added and the reaction mixture was heated to 85 °C and stirred for 4 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (30 mL) and filtered through diatomaceous earth. The organic layer was separated, washed with brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (220 g silica gel column, elution gradient 0 to 40% ethyl acetate/hexanes) to afford the target product 3-(2-methoxy-2-oxoethyl)phenylboronic acid pinacol ester (6.00 g, 100%) as a colorless oil. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.74 (s, 1H), 7.72 (s, 1H), 7.40 (t, J=1.7 Hz, 1H), 7.38-7.33 (m, 1H), 3.70 (s, 3H), 3.65 (s, 2H), 1.36 (s, 12H). lcmS (M+H) = 277.3; HPLC retention time = 0.99 min (column: BEH C18 2.1×50 mm; mobile phase A: water containing 0.05% TFA; mobile phase B: acetonitrile containing 0.05% TFA; gradient: 2-8% B in 1.6 min; flow rate: 0.8 mL/min).

References

[1] Patent: WO2015/100282, 2015, A1. Location in patent: Page/Page column 279
[2] Patent: US2016/176864, 2016, A1. Location in patent: Paragraph 0792; 0793
[3] Journal of Medicinal Chemistry, 2007, vol. 50, # 6, p. 1101 - 1115
[4] Patent: US2011/257172, 2011, A1. Location in patent: Page/Page column 19
[5] Patent: US2011/257173, 2011, A1. Location in patent: Page/Page column 19-21

Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate Suppliers

China 46 India 1 United States 9 Global 56

A.J Chemicals

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Email: sales@ajchem.in
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View Lastest Price from Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate manufacturers

Career Henan Chemical Co

Product: Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate 478375-42-7
Price: US $3.00/ASSAYS
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-09

478375-42-7, Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetateRelated Search:

methyl 2-[3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate

3-(2-Methoxy-2-oxoethyl)phenylboronic acid, pinacol ester

Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate

3-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl-acetic acid Methyl ester

Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)

Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxabo

Benzeneacetic acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester

Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate - [M23835]

478375-42-7