4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride
- Product Name
- 4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride
- CAS No.
- 666261-01-4
- Chemical Name
- 4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride
- Synonyms
- 4-(aminomethyl)oxan-4-ol hydrochloride;tetrahydro-2H-pyran-4-ol hydrochloride;4-(Aminomethyl)tetrahydro-2h-pyran-4-ol HCl;4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride;4-(aminomethyl)tetrahydro-1H-pyran-4-ol hydrochloroide
- CBNumber
- CB52566914
- Molecular Formula
- C6H14ClNO2
- Formula Weight
- 167.63386
- MOL File
- 666261-01-4.mol
4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride Property
- storage temp.
- 2-8°C
- Appearance
- White to light yellow Solid
- InChI
- InChI=1S/C6H13NO2.ClH/c7-5-6(8)1-3-9-4-2-6;/h8H,1-5,7H2;1H
- InChIKey
- ILUSBJDVXKZYEP-UHFFFAOYSA-N
- SMILES
- C1OCCC(CN)(O)C1.[H]Cl
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A622716
- Product name
- 4-Aminomethyltetrahydro-4H-pyran-4-olHydrochloride
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FA141840
- Product name
- 4-(Aminomethyl)tetrahydro-2H-pyran-4-ol hydrochloride
- Packaging
- 500mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- FA141840
- Product name
- 4-(Aminomethyl)tetrahydro-2H-pyran-4-ol hydrochloride
- Packaging
- 1g
- Price
- $135
- Updated
- 2021/12/16
- Product number
- P000377503
- Product name
- 4-(Aminomethyl)tetrahydro-2H-pyran-4-ol hydrochloride
- Purity
- 97%
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- OR321313
- Product name
- 4-(Aminomethyl)tetrahydro-2H-pyran-4-olhydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $153
- Updated
- 2021/12/16
4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride Chemical Properties,Usage,Production
Uses
4-Aminomethyltetrahydro-4H-pyran-4-ol Hydrochloride is a reagent used in the preparation of aminopyrimidinecarboxamides and their use as CB2-type cannabinoid receptor modulators.
Synthesis
50289-10-6
666261-01-4
LiAlH4 (18.7 g, 492 mmol) was added to a 2 L three-necked round-bottomed flask equipped with a top stirrer, thermocouple, dropping funnel, and nitrogen inlet and cooled to 0 °C, followed by the addition of anhydrous THF. 4-Hydroxytetrahydro-2H-pyran-4-carbonitrile (25.0 g, 196 mmol) was slowly added dropwise to the reaction mixture over a period of 1 h. The reaction was carried out in a 250 mL) solution. After the dropwise addition, the reaction mixture was warmed to room temperature and the dropping funnel was replaced with a reflux condenser and heated to reflux at 70 °C for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and further cooled to -10 °C in a dry ice acetone bath, followed by quenching the reaction with 2N NaOH solution (150 mL) until a white precipitate appeared. The reaction mixture was warmed to room temperature, diluted with ethyl acetate (500 mL) and stirred for 10 minutes. The precipitated solid was filtered through a diatomaceous earth pad and the diatomaceous earth pad was washed with ethyl acetate (300 mL). The filtrate was concentrated under reduced pressure to give a gelatinous liquid, which was dissolved in methyl tert-butyl ether (MTBE, 100 mL) and cooled to 0°C. A dioxane solution (100 mL) in 4N HCl was added dropwise to this solution and stirred at 0 °C for 30 min, followed by continued stirring at room temperature for 30 min. The precipitated solid was collected by vacuum filtration and dried over a constant flow of N2 gas to afford the target product 4-(aminomethyl)tetrahydro-2H-pyran-4-ol hydrochloride (21.0 g, 64% yield) as an off-white solid; Mass Spectrum (MS): m/z = 132 (M+H+).
References
[1] Patent: US2009/76062, 2009, A1. Location in patent: Page/Page column 22-23
[2] Patent: WO2005/74939, 2005, A1. Location in patent: Page/Page column 43-44; 62
[3] Patent: US2017/217986, 2017, A1. Location in patent: Paragraph 0513; 0514
[4] Patent: WO2004/29026, 2004, A1. Location in patent: Page 30-31
[5] Patent: WO2004/18433, 2004, A1. Location in patent: Page 54
4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride Preparation Products And Raw materials
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View Lastest Price from 4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride manufacturers
- Product
- 4-(AMinoMethyl)tetrahydro-2H-pyran-4-olhydrochloride 666261-01-4
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2020-01-13