5-(4-broMo-2-chlorophenylaMino)-4-fluoro-1-Methyl-1H-benzo[d]iMidazole-6-carboxylic acid

Product Name: 5-(4-broMo-2-chlorophenylaMino)-4-fluoro-1-Methyl-1H-benzo[d]iMidazole-6-carboxylic acid
CAS No.: 606144-04-1
Chemical Name: 5-(4-broMo-2-chlorophenylaMino)-4-fluoro-1-Methyl-1H-benzo[d]iMidazole-6-carboxylic acid
Synonyms: Prosulfocarb Impurity 1;1H-Benzimidazole-6-carboxylic acid, 5-[(4-bromo-2-chlorophen...;6-(4-bromo-2-chloroanilino)-7-fluoro-3-methylbenzimidazole-5-carboxylic acid;6-(4-Bromo-2-chlorophenylamino)-7-fluoro-3-methyl-benzimidazole-5-carboxylic acid;5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-1-methyl-1-benzimidazole-6-carboxylic Acid;5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylic acid;1H-BenziMidazole-6-carboxylic acid,5-[(4-broMo-2-chlorophenyl)aMino]-4-fluoro-1-Methyl-;6-(4-broMo-2-chlorophenylaMino)-7-fluoro-3-Methyl-3H-benzo[d]iMidazole-5-carboxylic acid;5-(4-broMo-2-chlorophenylaMino)-4-fluoro-1-Methyl-1H-benzo[d]iMidazole-6-carboxylic acid
CBNumber: CB52570445
Molecular Formula: C15H10BrClFN3O2
Formula Weight: 398.61
MOL File: 606144-04-1.mol

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5-(4-broMo-2-chlorophenylaMino)-4-fluoro-1-Methyl-1H-benzo[d]iMidazole-6-carboxylic acid Property

Boiling point:: 507.6±60.0 °C(Predicted)
Density: 1.75±0.1 g/cm3(Predicted)
pka: 4.18±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 095896
Product name: 5-((4-Bromo-2-chlorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylic acid
Purity: 95+%
Packaging: 1g
Price: $445
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0359062
Product name: 5-((4-BROMO-2-CHLOROPHENYL)AMINO)-4-FLUORO-1-METHYL-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $497.52
Updated: 2021/12/16

AK Scientific

Product number: Y6322
Product name: 5-((4-Bromo-2-chlorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylicacid
Packaging: 1g
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-M0259
Product name: 5-(4-bromo-2-chlorophenylamino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylicacid
Packaging: 1g
Price: $770
Updated: 2021/12/16

Matrix Scientific

Product number: 095896
Product name: 5-((4-Bromo-2-chlorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylic acid
Purity: 95+%
Packaging: 5g
Price: $885
Updated: 2021/12/16

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5-(4-broMo-2-chlorophenylaMino)-4-fluoro-1-Methyl-1H-benzo[d]iMidazole-6-carboxylic acid Chemical Properties,Usage,Production

Uses

5-((4-Bromo-2-chlorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylic Acid is a useful intermediate for organic synthesis processes. it is used in the preparation of selumetinib and it’s related impurities.

Synthesis

606144-02-9

606144-04-1

General procedure for the synthesis of 5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylic acid methyl ester: 5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylic acid methyl ester (2 g, from Example 4) was dissolved in tetrahydrofuran (20 mL), deionized water (10 mL) was added. and [d]imidazole-6-carboxylic acid methyl ester (2 g, from Example 4) was dissolved in tetrahydrofuran (20 mL), deionized water (10 mL) was added, and the reaction temperature was maintained at 25°C to 30°C. A solution of sodium hydroxide (0.74 g) in deionized water (4 mL) was added slowly and dropwise to the reaction mixture over 10 minutes at the same temperature. The reaction mixture was stirred continuously for 3 hours, maintaining the temperature at 25°C to 30°C. Upon completion of the reaction (monitored by TLC), tetrahydrofuran was removed by distillation under reduced pressure at 40 °C to 45 °C and deionized water (20 mL) was added. The aqueous phase was extracted with dichloromethane (2 x 20 mL). The aqueous phase was cooled to 5 °C to 10 °C, the pH was adjusted to 1.3 with 50% aqueous hydrochloric acid, and stirring was continued at 5 °C to 10 °C for 30 min. The precipitated solid was collected by filtration and washed with deionized water (2 x 20 mL). The wet solid was dried under reduced pressure at 35 °C to 40 °C for 14 h to afford the target product 5-((4-bromo-2-chlorophenyl)amino)-4-fluoro-1 -methyl-1H-benzo[d]imidazole-6-carboxylic acid in 88.5% yield.1H NMR (d6-DMSO, 400 MHz): δ 3.92 (s, 3H), 6.48-6.51 (m, 1H), 7.30-7.32 (m, 1H), 7.64-7.65 (d, 1H), 8.10 (s, 1H), 8.44 (s, 1H), 8.52 (s, 1H). Mass (m/z): 400.1 [M+2].

References

[1] Patent: WO2018/65924, 2018, A1. Location in patent: Page/Page column 10; 11
[2] Patent: US2004/116710, 2004, A1. Location in patent: Page 22
[3] Patent: WO2007/76245, 2007, A2. Location in patent: Page/Page column 20-21
[4] Patent: US2003/232869, 2003, A1. Location in patent: Page 10; 22; 23

5-(4-broMo-2-chlorophenylaMino)-4-fluoro-1-Methyl-1H-benzo[d]iMidazole-6-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(4-broMo-2-chlorophenylaMino)-4-fluoro-1-Methyl-1H-benzo[d]iMidazole-6-carboxylic acid Suppliers

China 59 United States 3 Global 62

Thoreau Chem Limited

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View Lastest Price from 5-(4-broMo-2-chlorophenylaMino)-4-fluoro-1-Methyl-1H-benzo[d]iMidazole-6-carboxylic acid manufacturers

Career Henan Chemical Co

Product: 5-(4-broMo-2-chlorophenylaMino)-4-fluoro-1-Methyl-1H-benzo[d]iMidazole-6-carboxylic acid 606144-04-1
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: ask
Release date: 2019-12-19

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5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylic acid

Prosulfocarb Impurity 1

5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-1-methyl-1-benzimidazole-6-carboxylic Acid

606144-04-1