A 784168

Product Name: A 784168
CAS No.: 824982-41-4
Chemical Name: A 784168
Synonyms: A 784168;Methyl syringate-d;3'-(Trifluoromethyl)-N-(4-((trifluoromethyl)sulfonyl)phenyl)-3,6-dihydro-2H-[1,2'-bipyridine]-;3'-(Trifluoromethyl)-N-(4-((trifluoromethyl)sulfonyl)phenyl)-3,6-dihydro-2H-[1,2'-bipyridine]-4-c;3,6-Dihydro-3'-(trifluoromethyl)-N-[4-[(trifluoromethyl)sulfonyl]phenyl]-[1(2H),2'-bipyridine]-4-carboxamide;[1(2H),2'-Bipyridine]-4-carboxamide, 3,6-dihydro-3'-(trifluoromethyl)-N-[4-[(trifluoromethyl)sulfonyl]phenyl]-;1-[3-(trifluoromethyl)pyridin-2-yl]-N-[4-(trifluoromethylsulfonyl)phenyl]-3,6-dihydro-2H-pyridine-4-carboxamide
CBNumber: CB52574685
Molecular Formula: C19H15F6N3O3S
Formula Weight: 479.3961192
MOL File: 824982-41-4.mol

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A 784168 Property

storage temp.: Store at RT
solubility: <47.94mg/ml in DMSO; <23.97mg/ml in ethanol
form: solid
color: Off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Tocris

Product number: 4319
Product name: A784168
Purity: ≥99%(HPLC)
Packaging: 10
Price: $219
Updated: 2021/12/16

Tocris

Product number: 4319
Product name: A784168
Purity: ≥99%(HPLC)
Packaging: 50
Price: $881
Updated: 2021/12/16

TRC

Product number: A965363
Product name: A784168
Packaging: 5mg
Price: $385
Updated: 2021/12/16

Usbiological

Product number: 254478
Product name: A 784168
Packaging: 10mg
Price: $466
Updated: 2021/12/16

ApexBio Technology

Product number: B5554
Product name: A784168
Packaging: 10mg
Price: $322
Updated: 2021/12/16

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A 784168 Chemical Properties,Usage,Production

Uses

A 784168 is a known TRPV1 antagonist.

Biological Activity

a 784168 is a potent antagonist of trpv1 receptor with pki value of 7.15 [1].the transient receptor potential cation channel subfamily v member 1 (trpv1) receptor is a nonselective cation channel and distributes throughout the nervous system. trpv1 receptor is activated by a wide variety of physical and chemical stimuli [1].a 784168 is a potent trpv1 receptor antagonist with pki value of 7.15 for recombinant htrpv1 receptor. in the ca2+ flux assay, a 784168 inhibited 50 nm cap-induced calcium flux with pic50 value of 7.13 of the recombinant htrpv1 receptor [1]. a 784168 inhibited trpv1 activation by 50 nm capsaicin, ph 5.5, 3 μm nada and 10 μm anandamide with ic50 values of 25, 14, 33.7, 35.1 nm, respectively. in rat dorsal root ganglion neurons, a 784168 inhibited 1 μm capsaicin-induced currents with ic50 value of 10 nm [2].in cfa-induced thermal hyperalgesia, a-784168 (30 μm/kg) reduced capsaicin-induced nocifensive behaviors with ed50 value of 10 μm/kg [2]. in rats, a 784168 inhibited 1% formalin-induced secondary mechanical hyperalgesia and allodynia in the contralateral and ipsilateral paws [3].

storage

Store at RT

References

[1]. bianchi br, el kouhen r, neelands tr, et al. [3h]a-778317 [1-((r)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (trpv1) receptor. j pharmacol exp ther, 2007, 323(1): 285-293.
[2]. cui m, honore p, zhong c, et al. trpv1 receptors in the cns play a key role in broad-spectrum analgesia of trpv1 antagonists. j neurosci, 2006, 26(37): 9385-9393.
[3]. martínez-rojas va, barragán-iglesias p, rocha-gonzález hi, et al. role of trpv1 and asic3 in formalin-induced secondary allodynia and hyperalgesia. pharmacol rep, 2014, 66(6): 964-971.

A 784168 Preparation Products And Raw materials

Raw materials

Preparation Products

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A 784168 Suppliers

China 24 United Kingdom 1 United States 5 USA 1 Global 31

EMMX Biotechnology LLC

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824982-41-4, A 784168Related Search:

A 784168

3'-(Trifluoromethyl)-N-(4-((trifluoromethyl)sulfonyl)phenyl)-3,6-dihydro-2H-[1,2'-bipyridine]-4-c

3'-(Trifluoromethyl)-N-(4-((trifluoromethyl)sulfonyl)phenyl)-3,6-dihydro-2H-[1,2'-bipyridine]-

1-[3-(trifluoromethyl)pyridin-2-yl]-N-[4-(trifluoromethylsulfonyl)phenyl]-3,6-dihydro-2H-pyridine-4-carboxamide

3,6-Dihydro-3'-(trifluoromethyl)-N-[4-[(trifluoromethyl)sulfonyl]phenyl]-[1(2H),2'-bipyridine]-4-carboxamide

[1(2H),2'-Bipyridine]-4-carboxamide, 3,6-dihydro-3'-(trifluoromethyl)-N-[4-[(trifluoromethyl)sulfonyl]phenyl]-

Methyl syringate-d

824982-41-4

C19H15F6N3O3S