ChemicalBook > CAS DataBase List > ATN-224

ATN-224

Product Name: ATN-224
CAS No.: 649749-10-0
Chemical Name: ATN-224
Synonyms: ATN-224;WTX-101);ATN 224,ATN224;ATN-224, 10 mM in DMSO;Choline tetrathiomolybdate;Bis(choline)tetrathioMolybdate;ATN-224 (Choline tetrathiomolybdate;CHOLINE TETRATHIOMOLYBDATE;WTX-101;WTX 101;WTX101;2-Hydroxy-N,N,N-trimethylethanaminium tetrathiomolybdate;bis(sulfanylidene)molybdenum,2-hydroxyethyl(trimethyl)azanium,sulfanide
CBNumber: CB52582927
Molecular Formula: C5H14MoNOS4-
Formula Weight: 328.36
MOL File: 649749-10-0.mol

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ATN-224 Property

storage temp.: Store at -20°C
solubility: DMSO:20.0(Max Conc. mg/mL);46.24(Max Conc. mM)
DMSO:PBS (pH 7.2):0.5(Max Conc. mg/mL);1.16(Max Conc. mM)
form: A crystalline solid
color: Pink to red
Water Solubility: H2O: ≥0.1mg/mL, clear

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3409
Product name: ATN-224
Purity: ≥95% (elemental analysis)
Packaging: 5MG
Price: $79.13
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3409
Product name: ATN-224
Purity: ≥95% (elemental analysis)
Packaging: 25MG
Price: $336
Updated: 2025/07/31

Cayman Chemical

Product number: 23553
Product name: ATN-224
Purity: ≥95%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 23553
Product name: ATN-224
Purity: ≥95%
Packaging: 5mg
Price: $214
Updated: 2024/03/01

Cayman Chemical

Product number: 23553
Product name: ATN-224
Purity: ≥95%
Packaging: 10mg
Price: $365
Updated: 2024/03/01

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ATN-224 Chemical Properties,Usage,Production

Description

ATN-224 is a choline salt of tetrathiomolybdate and an inhibitor of superoxide dismutase 1 (SOD1; IC₅₀s = 2.91 and 3.51 μM in human and mouse blood cells, respectively, in vitro). ATN-224 reduces the viability of cultured oxidative stress-resistant WEHI7.2 murine thymic lymphoma cells (EC₅₀s = 5-6 nM) and human diffuse large B cell lymphoma cell lines (EC₅₀s = 9.73-105.61 nM) independently of Bcl-2 and Bcl-xL. In vivo, ATN-224 (0.7 mg/kg) chelates copper to stabilize an antitumor viral vector, enhancing its efficacy against lung metastases in mice. It also inhibits angiogenesis in a mouse model (IC₅₀s = 1.50-3 mg/kg via gavage).

Uses

ATN-224 is an oral Cu2+/Zn2+-superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC50 of 17.5±3.7 nM.

in vivo

ATN-224 also significantly (P<0.05) inhibits angiogenesis in the Matrigel plug model in mice either when added directly to the plug or when given by oral gavage. Inhibition of angiogenesis when ATN-224 is given by oral gavage occurred before there is measurable depletion of copper in either plasma or copper from the Matrigel plug. This result shows that ATN-224 inhibits angiogenesis independently of copper depletion^[1].

References

[1] Juarez JC, et al. Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12(16):4974-82. DOI:10.1158/1078-0432.CCR-06-0171
[2] Lin J, et al. A non-comparative randomized phase II study of 2 doses of ATN-224, a copper/zinc superoxide dismutase inhibitor, in patients with biochemically recurrent hormone-na?ve prostate cancer. Urol Oncol. 2013 Jul;31(5):581-8. DOI:10.1016/j.urolonc.2011.04.009

ATN-224 Preparation Products And Raw materials

Raw materials

Preparation Products

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ATN-224 Suppliers

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649749-10-0, ATN-224Related Search:

ATN-224

Bis(choline)tetrathioMolybdate

ATN-224 (Choline tetrathiomolybdate

WTX-101)

Choline tetrathiomolybdate

CHOLINE TETRATHIOMOLYBDATE;WTX-101;WTX 101;WTX101

bis(sulfanylidene)molybdenum,2-hydroxyethyl(trimethyl)azanium,sulfanide

2-Hydroxy-N,N,N-trimethylethanaminium tetrathiomolybdate

ATN 224,ATN224

ATN-224, 10 mM in DMSO

649749-10-0

2C5H14NOMoS4

C10H32MoN2O2S4