2-chloro-6-(trifluoroMethoxy)pyridine

Product Name: 2-chloro-6-(trifluoroMethoxy)pyridine
CAS No.: 1221171-70-5
Chemical Name: 2-chloro-6-(trifluoroMethoxy)pyridine
Synonyms: 2-chloro-6-(trifluoroMethoxy)pyridine;Pyridine, 2-chloro-6-(trifluoromethoxy)-
CBNumber: CB52589249
Molecular Formula: C6H3ClF3NO
Formula Weight: 197.54
MOL File: 1221171-70-5.mol

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2-chloro-6-(trifluoroMethoxy)pyridine Property

Boiling point:: 42-44 °C(Press: 15 Torr)
Density: 1.463±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: -3.87±0.10(Predicted)
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C6H3ClF3NO/c7-4-2-1-3-5(11-4)12-6(8,9)10/h1-3H
InChIKey: GZFNUCAMADABAO-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(OC(F)(F)F)=CC=C1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C421910
Product name: 2-Chloro-6-(trifluoromethoxy)pyridine
Packaging: 100mg
Price: $160
Updated: 2021/12/16

TRC

Product number: C421910
Product name: 2-Chloro-6-(trifluoromethoxy)pyridine
Packaging: 1g
Price: $1260
Updated: 2021/12/16

Matrix Scientific

Product number: 102735
Product name: 2-Chloro-6-(trifluoromethoxy)pyridine
Purity: 97%
Packaging: 500mg
Price: $101
Updated: 2021/12/16

AK Scientific

Product number: 5522AJ
Product name: 2-Chloro-6-(trifluoromethoxy)pyridine
Packaging: 250mg
Price: $134
Updated: 2021/12/16

Matrix Scientific

Product number: 102735
Product name: 2-Chloro-6-(trifluoromethoxy)pyridine
Purity: 97%
Packaging: 1g
Price: $155
Updated: 2021/12/16

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2-chloro-6-(trifluoroMethoxy)pyridine Chemical Properties,Usage,Production

Uses

2-Chloro-6-(trifluoromethoxy)pyridine is used in the synthesis of anti-HCV agents.

Synthesis

1221171-69-2

1221171-70-5

(b) Synthesis of 2-chloro-6-(trifluoromethoxy)pyridine (1-5): a mixture of SbF3 (29.87 g, 167.10 mmol, 2 eq.) and SbCl5 (1.61 mL, 12.53 mmol, 0.15 eq.) was stirred at 120 °C under argon protection. Subsequently, 2-chloro-6-(trichloromethoxy)pyridine (20.63 g, 83.55 mmol, 1 eq.) was added slowly and dropwise over 20 min. The reaction mixture was continued to be stirred at 120 °C for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and diluted with the addition of dichloromethane (350 mL), followed by the addition of saturated sodium carbonate solution (350 mL) and 20% KF aqueous solution (175 mL) sequentially. The resulting biphasic mixture was filtered through Celite. The organic and aqueous layers were separated and the aqueous layer was extracted repeatedly with dichloromethane (5 x 100 mL). All organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated to dryness. The crude product was purified by vacuum distillation (pressure = 35 mbar, temperature = 81-83 °C) to afford 2-chloro-6-(trifluoromethoxy)pyridine as a colorless oil in 62% yield.1H NMR (CDCl3) δ (ppm): 6.96 (d, 1H), 7.27 (d, 1H), 7.75 (t, 1H).

References

[1] Patent: WO2012/93174, 2012, A1. Location in patent: Page/Page column 38
[2] Patent: WO2010/40461, 2010, A1. Location in patent: Page/Page column 17-18
[3] European Journal of Organic Chemistry, 2010, # 31, p. 6043 - 6066
[4] ChemMedChem, 2015, vol. 10, # 4, p. 715 - 726
[5] Journal of Fluorine Chemistry, 2017, vol. 203, p. 155 - 165

2-chloro-6-(trifluoroMethoxy)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-chloro-6-(trifluoroMethoxy)pyridine Suppliers

Canada 1 China 78 India 1 United Kingdom 2 United States 7 Global 89

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View Lastest Price from 2-chloro-6-(trifluoroMethoxy)pyridine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-chloro-6-(trifluoroMethoxy)pyridine 1221171-70-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-09

Career Henan Chemical Co

Product: 2-chloro-6-(trifluoroMethoxy)pyridine 1221171-70-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-30

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1221171-70-5