6-chloro-4-iodo-3-Methoxypyridazine
- Product Name
- 6-chloro-4-iodo-3-Methoxypyridazine
- CAS No.
- 181355-92-0
- Chemical Name
- 6-chloro-4-iodo-3-Methoxypyridazine
- Synonyms
- 6-chloro-4-iodo-3-Methoxypyridazine;Pyridazine, 6-chloro-4-iodo-3-methoxy-
- CBNumber
- CB52589269
- Molecular Formula
- C5H4ClIN2O
- Formula Weight
- 270.46
- MOL File
- 181355-92-0.mol
6-chloro-4-iodo-3-Methoxypyridazine Property
- Boiling point:
- 371.5±42.0 °C(Predicted)
- Density
- 2.019±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -1.01±0.10(Predicted)
- InChI
- InChI=1S/C5H4ClIN2O/c1-10-5-3(7)2-4(6)8-9-5/h2H,1H3
- InChIKey
- AWEZJAIGNOXBAI-UHFFFAOYSA-N
- SMILES
- C1(OC)=NN=C(Cl)C=C1I
N-Bromosuccinimide Price
- Product number
- C601768
- Product name
- 6-Chloro-4-iodo-3-methoxypyridazine
- Packaging
- 25mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 7494DA
- Product name
- 6-Chloro-4-iodo-3-methoxypyridazine
- Packaging
- 1g
- Price
- $238
- Updated
- 2021/12/16
- Product number
- HCH0367951
- Product name
- 6-CHLORO-4-IODO-3-METHOXYPYRIDAZINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.06
- Updated
- 2021/12/16
- Product number
- 181355920
- Product name
- 6-Chloro-4-iodo-3-methoxypyridazine
- Packaging
- 250mg
- Price
- $164.16
- Updated
- 2021/12/16
- Product number
- CM127919
- Product name
- 6-chloro-4-iodo-3-methoxypyridazine
- Purity
- 97%
- Packaging
- 1g
- Price
- $355
- Updated
- 2021/12/16
6-chloro-4-iodo-3-Methoxypyridazine Chemical Properties,Usage,Production
Uses
6-?Chloro-?4-?iodo-?3-?methoxypyridazine is a reagent used in the preparation of low ATP kinase inhibitors.
Synthesis
1722-10-7
181355-92-0
General procedure for the synthesis of 6-chloro-4-iodo-3-methoxypyridazine from 6-methoxy-3-chloropyridazine: n-butyllithium (16 mL, 2.5 M hexane solution, 40 mmol) was slowly added to a stirred solution of 2,2,6,6-tetramethylpiperidine (6.9 mL, 41 mmol) in tetrahydrofuran (200 mL, 2.5 mol) at -70°C . Subsequently, 3-chloro-6-methoxypyridazine (2.90 g, 20.1 mmol) dissolved in tetrahydrofuran (150 mL) was added dropwise and the reaction mixture was stirred at -78°C for 30 min. Next, iodine (5.30 g, 20.9 mmol) dissolved in tetrahydrofuran (50 mL) was added and stirring was continued at -78°C for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of 1 M aqueous sodium thiosulfate (150 mL) and the mixture was extracted with ether. The organic phase was dried with magnesium sulfate, filtered and the solvent was removed in vacuum. Purification by silica gel column chromatography afforded 925 mg of 6-chloro-4-iodo-3-methoxypyridazine.LC-MS (Method 5): retention time R = 2.94 min; MS (ESIpos): m/z = 271 [M + H]+. 1H-NMR (400 MHz, DMSO-d6) δ [ppm]: 2.495 (0.64). 2.500 (0.88), 2.505 (0.64), 3.316 (11.53), 3.992 (0.76), 4.049 (16.00), 8.416 (5.48).
References
[1] Patent: WO2010/56875, 2010, A1. Location in patent: Page/Page column 95
[2] Patent: EP2527344, 2012, A1. Location in patent: Page/Page column 36-37
[3] Patent: WO2012/160030, 2012, A1. Location in patent: Page/Page column 142-143
[4] Patent: WO2017/102091, 2017, A1. Location in patent: Page/Page column 454
6-chloro-4-iodo-3-Methoxypyridazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-chloro-4-iodo-3-Methoxypyridazine manufacturers
- Product
- 6-chloro-4-iodo-3-methoxypyridazine 181355-92-0
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 100kg
- Release date
- 2019-12-23