JTE-013

ChemicalBook > CAS DataBase List > JTE-013

Product Name: JTE-013
CAS No.: 383150-41-2
Chemical Name: JTE-013
Synonyms: CS-2553;JTE-013 HCl;JTE-013;JTE 013;JTE013;LPL Receptor,Apoptosis,JTE-013,Inhibitor,Lysophospholipid Receptor,JTE 013,inhibit,JTE013;1-(2,6-dichloro-4-pyridyl)-3-[(4-isopropyl-1,3-dimethyl-pyrazolo[3,4-b]pyridin-6-yl)amino]urea;1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea;1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide;1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(2,6-dichloro-4-pyridinyl)-semicarbazide;N-(2,6-Dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazine-1-carboxamide;N-(2,6-Dichloro-4-pyridinyl)-2-[1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]hydrazinecarboxamide
CBNumber: CB52591408
Molecular Formula: C17H19Cl2N7O
Formula Weight: 408.29
MOL File: 383150-41-2.mol

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JTE-013 Property

Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥20mg/mL
pka: 9.32±0.43(Predicted)
form: powder
color: white to off-white

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: J4080
Product name: JTE-013
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $155
Updated: 2024/03/01

Sigma-Aldrich

Product number: J4080
Product name: JTE-013
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $613
Updated: 2024/03/01

Cayman Chemical

Product number: 10009458
Product name: JTE-013
Purity: ≥98%
Packaging: 1mg
Price: $26
Updated: 2024/03/01

Cayman Chemical

Product number: 10009458
Product name: JTE-013
Purity: ≥98%
Packaging: 5mg
Price: $98
Updated: 2024/03/01

Cayman Chemical

Product number: 10009458
Product name: JTE-013
Purity: ≥98%
Packaging: 10mg
Price: $135
Updated: 2024/03/01

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JTE-013 Chemical Properties,Usage,Production

Description

Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P₁/EDG-1, S1P₂/EDG-5, S1P₃/EDG-3, S1P₄/EDG-6, and S1P₅/EDG-8. JTE-013 is a potent, selective sphingosine-1-phosphate 2 (S1P₂) receptor antagonist that binds to the human and rat receptors with IC₅₀ values of 17 and 22 nM, respectively, (IC₅₀ values >10 μM for human S1P₁ and S1P₃). It reverses the inhibitory effects of S1P on cell migration of vascular endothelial cells and smooth muscle cells. Similarly, JTE-013 reverses the inhibition of S1P on invasion and migration of B16 melanoma cells. JTE-013 inhibits S1P-induced contraction of, as well as cyclic AMP accumulation in, coronary artery smooth muscle cells.

Uses

JTE-013 has been used in in vitro blood?brain barrier (BBB) and blood?tumor barrier (BTB) assays.

Definition

ChEBI: 1-(2,6-dichloro-4-pyridinyl)-3-[(1,3-dimethyl-4-propan-2-yl-6-pyrazolo[3,4-b]pyridinyl)amino]urea is a pyrazolopyridine.

Biochem/physiol Actions

JTE-013 can enhance the excitability of small-diameter sensory neurons. It has the ability to repress sphingosine 1-phosphate (S1P)-mediated cellular migration.

storage

Store at +4°C

JTE-013 Preparation Products And Raw materials

Raw materials

Preparation Products

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383150-41-2, JTE-013Related Search:

1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(2,6-dichloro-4-pyridinyl)-semicarbazide

1-(2,6-dichloro-4-pyridyl)-3-[(4-isopropyl-1,3-dimethyl-pyrazolo[3,4-b]pyridin-6-yl)amino]urea

1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide

CS-2553

N-(2,6-Dichloro-4-pyridinyl)-2-[1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]hydrazinecarboxamide

JTE-013;JTE 013;JTE013

1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea

Hydrazinecarboxamide, N-(2,6-dichloro-4-pyridinyl)-2-[1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-

N-(2,6-Dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazine-1-carboxamide

JTE-013 HCl

LPL Receptor,Apoptosis,JTE-013,Inhibitor,Lysophospholipid Receptor,JTE 013,inhibit,JTE013

383150-41-2

C17H19Cl2N7O