ChemicalBook > CAS DataBase List > NVP-AEW541 (hydrochloride)
NVP-AEW541 (hydrochloride)
- Product Name
- NVP-AEW541 (hydrochloride)
- CAS No.
- 2320261-63-8
- Chemical Name
- NVP-AEW541 (hydrochloride)
- Synonyms
- AEW541 HCl;NVP-AEW541 (hydrochloride);7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine,dihydrochloride
- CBNumber
- CB52591882
- Molecular Formula
- C27H30ClN5O
- Formula Weight
- 476.02
- MOL File
- 2320261-63-8.mol
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NVP-AEW541 (hydrochloride) Property
- solubility
- Ethanol: 0.3 mg/ml; PBS (pH 7.2): 2.5 mg/ml
- form
- A crystalline solid
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 13641
- Product name
- NVP-AEW541 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $81
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13641
- Product name
- NVP-AEW541 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $117
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13641
- Product name
- NVP-AEW541 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $437
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13641
- Product name
- NVP-AEW541 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $765
- Updated
- 2024/03/01
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NVP-AEW541 (hydrochloride) Chemical Properties,Usage,Production
Description
AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP- AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. Note: AEW541 has a Cis-configuration on the cyclobutane ring. Its CAS# is 475489-16-8. Many vendors and Sc-finder scholar made mistake - AEW541 was mistakenly listed as CAS#475488-34-7, the trans-isomer of AEW541. The correct structure of AEW541 can be confirmed from Joel Slade, et al (from Novartis), Org. Process Res. Dev. 2007, 11, 5, 825–835.
NVP-AEW541 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
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NVP-AEW541 (hydrochloride) Suppliers
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- 400-9205774
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- Country
- China
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- China
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- 021-65675885 18964387627
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- China
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- Advantage
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