OU749
- Product Name
- OU749
- CAS No.
- 519170-13-9
- Chemical Name
- OU749
- Synonyms
- OU749;N-[5-(4-Methoxybenzyl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide;N-[5-[(4-methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]-benzenesulfonamide;Benzenesulfonamide, N-[5-[(4-methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]-
- CBNumber
- CB52591897
- Molecular Formula
- C16H15N3O3S2
- Formula Weight
- 361.44
- MOL File
- 519170-13-9.mol
OU749 Property
- storage temp.
- 2-8°C
- solubility
- DMSO: >20mg/mL
- form
- solid
- color
- white to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 13804
- Product name
- OU749
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $23
- Updated
- 2024/03/01
- Product number
- 13804
- Product name
- OU749
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 13804
- Product name
- OU749
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $177
- Updated
- 2024/03/01
- Product number
- 13804
- Product name
- OU749
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $384
- Updated
- 2024/03/01
- Product number
- C4135
- Product name
- OU749
- Packaging
- 25mg
- Price
- $437
- Updated
- 2021/12/16
OU749 Chemical Properties,Usage,Production
Biological Activity
ou749 is a competitive inhibitor of γ-glutamyl transpeptidase (ggt) [1].expression of γ-glutamyl transpeptidase (ggt) in tumors contributes to the resistance to radiation and chemotherapy. ggt is inhibited by glutamine analogues which compete with the substrate for the γ-glutamyl binding site [1].ou749 inhibited human kidney ggt with an intrinsic ki of 17.6 m [1]. in 786-o cells, a human renal tumor cell line, ou749 showed more than 150-fold less toxic than the ggt inhibitor acivicin toward dividing cells. ou749 inhibited ggt isolated from human kidney in a dose-dependent manner [1]. ou749 was 7-fold less potent as inhibitor of ggt isolated from rat kidney and 10-fold less potent inhibiting ggt from mouse kidney [1]. ou749 did not inhibit degradation of glutathione by ggt from rat kidney. inhibition of ggt by ou749 is species-specific [1]. ou749 showed no inhibitory effect on ggt from pig cells. ou749 inhibited human ggt expressed in mouse fibroblasts by a similar extent to the ggt from human cells, indicated that the species specificity was determined by differences in the primary structure of the protein rather than species-specific, post-translational modifications [1].
References
[1] king j b, west m b, cook p f, et al. a novel, species-specific class of uncompetitive inhibitors of γ-glutamyl transpeptidase[j]. journal of biological chemistry, 2009, 284(14): 9059-9065.
OU749 Preparation Products And Raw materials
Raw materials
Preparation Products
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